BioSpace News Archive

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MASH

Altimmune Nosedives on Mixed Mid-Stage MASH Data for GLP-1/Glucagon Drug

Altimmune’s pemvidutide failed to significantly improve fibrosis in MASH patients in a Phase IIb study. The biotech crashed 53% in the aftermath of the readout.

June 27, 2025

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2 min read

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Tristan Manalac

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Neurodegenerative disease

Edgewise Takes a Hit as FDA Blocks Accelerated Path for Becker Muscular Dystrophy Drug

The FDA found that data from a single Phase II study were “insufficient” to justify an accelerated approval review for sevasemten in Becker muscular dystrophy.

June 27, 2025

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2 min read

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Tristan Manalac

Vaccines

ACIP Skips Votes on COVID and Moderna’s mRESVIA but Scrutinzes mRNA Vaccine Safety

The revamped and “more anti-vax skewed ACIP committee” at the CDC “has a bone to pick with mRNA vaccines,” according to Truist Securities analysts. Meanwhile, the FDA moves forward on having Pfizer/BioNTech and Moderna update labels for their COVID vaccines.

June 27, 2025

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2 min read

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Jef Akst

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Obesity

Analysts Home In on Safety as Novo, Lilly, Amgen Highlight Weight Loss Data at ADA

In the race to make the most tolerable obesity drug, there seems to be no clear winner—at least not according to analysts parsing the data presented at the American Diabetes Association annual meeting this week.

June 27, 2025

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5 min read

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Heather McKenzie

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Collaboration

Alphabet Subsidiary Calico Colors In Up To $570M+ Aging Deal With China’s Mabwell

Calico will leverage 9MW3811’s anti-inflammatory mechanism to advance its mission of addressing aging-related diseases.

June 27, 2025

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2 min read

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Tristan Manalac

Depression

Alto Digs Into Exploratory Outcomes as Depression Drug Misses Phase II Endpoint

While ALTO-203 missed its depression-related endpoints, improvements in EEG biomarkers, attention and wakefulness point to signals of drug activity, William Blair said, though the analysts pointed to other indications as potentially more promising for future development.

June 27, 2025

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2 min read

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Tristan Manalac

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Legal

Supreme Court Leaves PrEP Drug Coverage Decisions to RFK’s Task Force

The high court found that members of a task force that determines what preventive drugs must be covered can be removed at will by HHS Secretary Robert F. Kennedy Jr.

June 27, 2025

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2 min read

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Annalee Armstrong

Press Releases

Acarix Applauds New Peer-Reviewed Study Demonstrating Cost-Effectiveness of the CADScor®System in U.S. Emergency Departments

June 27, 2025

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3 min read

Press Releases

Baylor Genetics Applauds New Guidance from American Academy of Pediatrics for Genome and Exome Sequencing to be used as First-Tier Tests for Children with Certain Developmental Delays