For women with severe premenstrual syndrome, the antidepressant drug sertraline brings relief -- and it makes no difference if they take the drug continuously or just before their periods. Dr. Ellen W. Freeman, of the University of Pennsylvania School of Medicine, Philadelphia, and colleagues assigned 167 women with premenstrual mood problems to receive continuous sertraline (also known as Zoloft), intermittent sertraline, or an inactive placebo.
