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Company Profile


Genocea Biosciences 

100 Acorn Park Drive

Cambridge  Massachusetts  02140  U.S.A.
Phone: 617-876-8191 Fax: 617-876-8192


Genocea aims to transform vaccine discovery and development to improve millions of lives. We use ATLAS™, our proprietary technology platform that rapidly identifies T cell antigens associated with protective immune responses in humans exposed to a pathogen. We have a pipeline of novel vaccine candidates that stimulate the T cell arm of the immune system, which is increasingly recognized as critical to generating protective immunity against a wide array of diseases.

Genocea’s pipeline includes programs addressing genital herpes, pneumococcus, chlamydia, malaria and cancer immunotherapy. We currently have two products in Phase 2 clinical development:

• GEN-003, an immunotherapy to treat patients with genital herpes. We reported positive top-line data from an ongoing Phase 2b dose optimization trial from the immediate post dosing 28-day observation period in May 2015. We identified an improved dose of 60µg per protein/75µg of adjuvant, which demonstrated a highly statistically significant reduction (p>0.0001) from baseline in the viral shedding rate (55%) and genital lesion rate (60%). Data from the six-month and 12-month observation periods in this trial is expected in the fourth quarter of 2015 and the first quarter of 2016, respectively.

Data from the prior Phase 1/2a trial was the first time a therapeutic vaccine candidate has demonstrated significant reductions in the rates of viral shedding and genital lesions in genital herpes patients.

• GEN-004, a universal vaccine which is in Phase 2 development to prevent infections caused by all serotypes of pneumococcus. We have completed enrollment in a Phase 2 human challenge clinical trial and expect to report top-line data in the fourth quarter of 2015.

In a prior Phase 1 study, GEN-004 met its safety, tolerability and immunogenicity goals, including measurable increases in the blood of T helper 17 (TH17) cells, a rare cell type that provides immunity at epithelial and mucosal surfaces.

Key Statistics

Ownership: Public

Web Site: Genocea
Symbol: GNCA

Company News
3 Life Sciences Companies Heading Into Orbit or On the Launching Pad 4/13/2016 6:53:08 AM
Genocea (GNCA) Stock Doubles After Market Yesterday on Positive 12 Months Genital Herpes Data 3/31/2016 12:55:02 PM
10 Massachusetts Biotechs that Grew Their Headcount by at Least 40% in 2015 3/23/2016 6:40:48 AM
Genocea (GNCA) To Present At The Piper Jaffray 27th Annual Healthcare Conference 11/24/2015 9:39:35 AM
Genocea (GNCA) To Present At The Stifel 2015 Healthcare Conference 11/11/2015 10:58:23 AM
Genocea (GNCA) Reports Third Quarter 2015 Financial Results 11/5/2015 1:36:31 PM
Genocea (GNCA) Announces Immuno-Oncology Research Collaboration With Memorial Sloan-Kettering Cancer Center 11/5/2015 1:07:15 PM
Genocea (GNCA) Presents Positive Findings From ATLASTM Immuno-Oncology Research Collaboration At 2015 SITC Annual Meeting 11/4/2015 11:15:35 AM
Genocea (GNCA) To Host Third Quarter 2015 Financial Results Conference Call & Webcast On November 5, 2015 10/29/2015 11:26:58 AM
Genocea (GNCA) Announces Publications Highlighting ATLAS T Cell Antigen Discovery Efforts In Chlamydia And Malaria 10/27/2015 11:16:29 AM