WASHINGTON, DC--(MARKET WIRE)--Jun 12, 2006 -- New analyses from the landmark PROactive Study found that ACTOS® (pioglitazone HCl), an oral antidiabetic medication, significantly reduced the occurrence of major adverse cardiovascular events (MACE) such as heart attacks (excluding silent heart attacks), nonfatal stroke, acute coronary syndrome (ACS) and cardiovascular death in high-risk patients with type 2 diabetes. Additionally, results showed that ACTOS significantly decreased the progression to permanent insulin use. These results were presented as three separate abstracts at the American Diabetes Association (ADA) 66th Annual Scientific Sessions.