Protherics PLC Announces Holding(s) in Company

London, UK; Brentwood, TN, US; 4 June 2007 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that, on 1 June 2007, a notification of interest in the ordinary share capital of the Company was received from Aviva plc as follows:
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