The global protein expression market size was USD 2.20 Billion in 2020 and is expected to register a revenue CAGR of 13.5% during the forecast period.
The global protein expression market size was USD 2.20 Billion in 2020 and is expected to register a revenue CAGR of 13.5% during the forecast period.
Key factors driving global market revenue growth are increasing prevalence of chronic and autoimmune diseases globally, rapidly expanding biopharmaceutical and biotechnology sectors, and availability of favorable reimbursement facilities in various developed countries.
Over the recent years, protein expression has become a crucial laboratory technology in molecular biology, research, and biochemistry, along with scientific research fields that work with functional proteins. Protein expression is a process in which protein synthesis, modification, and regulation take place inside living organisms. It is carried out through 3 main processes including translation, transcription, and post-translational modification.
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Recent progress in the field of recombinant DNA technology is leading to production of recombinant proteins used as vaccines, therapeutics, and diagnostic reagents. Recombinant proteins are produced using prokaryotic or eukaryotic expression host systems such as bacteria, insect cells, yeast, and mammalian cells and are widely used for therapeutic, research, and industrial applications. Increasing prevalence of various diseases such as cardiovascular diseases, genetic disorders, cancer, and diabetes is leading to rapid increase in demand for therapeutic proteins such as hormones, vaccines, monoclonal antibodies, and insulin. Thus, various major companies are focusing on developing and manufacturing enhanced therapeutic drugs and proteins for treating various chronic conditions such as cancer, anemia, multiple sclerosis, and anemia, among others.
The global protein expression market is expected to be significantly driven by ongoing research on isolation and expression of recombinant protein, as well as rapidly growing biotechnology and molecular genetics sectors. Rising investments in proteomics by private and government organizations, improving healthcare facilities, rising healthcare expenditure, increasing public awareness about protein expression, and rapid developments in disease detection technology are other factors expected to boost revenue growth of the global market in the years to come. Moreover, rapid advancements in genetic engineering and recombinant technologies are resulting in increasing focus of manufacturers on exploring functional characteristics of proteins without affecting product efficacy and safety.
However, market revenue growth could be hampered substantially due to certain unfavorable factors such as lack of skilled healthcare experts in research laboratories and pharmaceutical companies to operate complex machines and instruments, as well as changes in the form of recombinant proteins that may reduce effectiveness of therapeutic protein and cause various side effects.
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Market Dynamics:
Drivers: Growing Prevalence of Chronic Diseases and Increasing Geriatric Population
Increasing prevalence of chronic diseases such as cancer, diabetes, multiple sclerosis, and genetic disorders is expected to boost market growth. In addition, changing lifestyles and increasing geriatric population would contribute to market growth in the forecast period. High possibility of geriatric population suffering from age-related illnesses and infections is propelling demand for protein therapeutics and biologics. Also, increasing adoption of protein-based drugs, rapid advancements in proteomics and biotechnology sector, availability of funds for proteomics research in many developed and developing countries, and increasing investments in R&D activities are expected to boost market growth over the forthcoming years.
Restraint: Requirement of High Investments for Research & Development
Many research institutes and pharmaceutical and biotechnology companies, especially in developing countries, face challenges with budget constraints and lack of funds for research and instruments. In addition, factors such as high initial investments for research and stringent regulatory policies for product approval are expected to hamper global market growth between 2021 and 2030. High chances of contamination during protein purification and high cost of reagents and instruments required for protein expression are also expected to hamper overall market growth in the near future.
Key Takeaways:
Expression Systems Outlook:
Based on expression systems, the global protein expression market is broadly segmented into prokaryotic expression systems, mammalian cell systems, insect cell systems, yeast systems, cell-free expression systems, and others. Prokaryotic systems segment is expected to register significant revenue share over the forecast period, owing to increasing investments in research & development activities, high production capacity at minimal costs, and growing usage of prokaryotic systems in drug production and biologics. Escherichia coli is the most preferred choice for protein expression and production of recombinant protein. Escherichia coli is a well-established host that offers rapid expression, easy genetic manipulation in low cost media, requires minimum culturing time, and is capable of producing a wide range of proteins.
Product Outlook:
Based on product type, the global market is segmented into reagents, competent cells, expression vectors, services, and instruments. Reagents segment is expected to account for largest revenue share between 2021 and 2030, owing to rising demand for various reagents and materials from pharmaceutical and biotechnology companies, as well as research institutes. In addition, increasing research & development activities in the protein expression field and higher focus on developing advanced vaccines and therapeutics using unique reagents and kits to prevent chronic diseases would also propel growth of this segment.
Application Outlook:
Based on application, the global protein expression market is segmented into therapeutic, industrial, and research. Research segment is expected to register fastest revenue CAGR throughout the forecast period, owing to increasing prevalence of chronic diseases such as arthritis, diabetes, cancer, and infectious diseases, rising investments in ongoing genomics and proteomics-based research, and high demand for precision medicine. Increasing focus on exploring the potential of cell-free protein synthesis and funds offered by various private and public organizations are other factors expected to drive growth of this segment during the forecast period.
Therapeutic segment, on the other hand, accounted for significant revenue share in 2020, owing to factors such as increasing prevalence of chronic and infectious diseases and rising investments in developing enhanced protein therapeutics. In addition, increasing usage of therapeutic proteins such as IFNs, cytokines, and monoclonal antibodies for treating various cancers, HIV, tuberculosis, malaria, cardiovascular diseases, and other diseases is expected to boost growth of this segment.
End-use Outlook:
Based on end-use, the global market is segmented into pharmaceutical and biotechnology companies, academic and research institutes, contract research organizations, and others. Among these, pharmaceutical and biotechnology companies segment is expected to account for largest revenue share during the forecast period. This can be attributed to factors such as rapid advancements in protein expression systems, increasing demand for therapeutic proteins, and rising number of pharmaceutical and biotechnology companies worldwide. In addition, increasing investments in research & development activities, ongoing research-based activities on proteomics, and high focus on developing new biologics are other factors driving growth of the segment.
Regional Outlook:
Geographically, North America is expected to account for largest revenue share in the global market between 2021 and 2030, owing to presence of a huge patient pool, high healthcare expenditure, rapidly expanding biotechnology and biopharmaceutical sectors, rising demand for precision medicine, and presence of leading market players. Other factors such as rapid advancements in protein expression, increasing demand for protein biologics, high focus on research & development process, and rising investments for research by various public and private organizations are fueling market growth in North America.
Asia Pacific market is expected to register rapid revenue CAGR over the forecast period, owing to rising healthcare expenditure, increasing incidence of chronic diseases and autoimmune disorders, improvements in healthcare facilities and research infrastructure, and rising funds for protein-based research by public and private sectors. Ongoing research on recombinant-based protein expression, increasing investments in research & development activities, and high geriatric population are other factors driving Asia Pacific market growth.
Competitive Landscape:
The global protein expression market is extremely competitive and comprises various key players at regional and global levels. Major players in the market are focused on product development and are adopting various strategies such as license agreements, mergers and acquisitions, investments in research and development activities, collaborations, and partnerships to expand their product base and strengthen their market position. Some major companies profiled in the market report are Agilent Technologies, Inc., Thermo Fisher Scientific Inc., Bio-Rad Laboratories, Inc., Merck KGaA, Promega Corporation, New England Biolabs, Qiagen, Takara Bio, Inc., Sino Biological Inc., Proteona, Genscript Biotech Corporation, ProteoGenix., Bioneer Corporation, Peak Proteins Ltd., Oxford Expression Technologies Ltd., ARTES Biotechnology GmbH, and Synthetic Genomics Inc.
Strategic Developments:
- In October 2020, TherapeutAix collaborated with Peak Proteins and Alderley Analytical to support a TherapeutAix client in overcoming an unusual and challenging PK/PD situation. This collaboration resulted in the combination of expertise and vital data was generated at a fast pace to address the PK/PD challenge.
Pipeline Analysis:
In 2019, Proteona Pte. Ltd. launched ESCAPE proteogenomics assay for Chimeric Antigen Receptor (CAR)T cell characterization. ESCAPE single cell analysis with protein expression is the first commercial service for characterization of both protein expression and RNA levels across thousands of single CART cells. It uses DNA-barcoded antibodies for capturing gene expression and proteomic data simultaneously at single cell level.
Segments Covered in the report
This report offers historical data and forecasts revenue growth at a global, regional, and country level, and provides analysis of the market trends in each of the sub-segments from 2018 to 2030. For the purpose of this study, Reports and Data has segmented the global protein expression market based on expression systems, product, application, end-use, and region:
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Protein Expression Market Report Scope
Segments covered By Expression Systems Outlook, Product Outlook, Application Outlook, End-use Outlook, Regional Outlook
By Expression Systems Outlook
- Prokaryotic Expression Systems
- Escherichia coli Systems
- Others
- Mammalian Cell Systems
- Insect Cell systems
- Baculovirus Expression Systems
- Others
- Yeast Systems
- Kluyveromyces Lactis Systems
- Saccharomyces Systems
- Pichia Systems
- Others
- Cell-free Expression Systems
- Others
By Product Outlook
- Reagents
- Competent Cells
- Expression Vectors
- Services
- Instruments
By Application Outlook
- Therapeutic
- Industrial
- Research
By End-use Outlook
- Pharmaceutical & Biotechnology Companies
- Academic & Research Institutes
- Contract Research Organizations
- Others
Regional scope
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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