Pain relief drugs called COX inhibitors seem to reduce the blood pressure-lowering effects of ACE inhibitors, a group that includes drugs like Zestril and Monopril, new research suggests. This drug interaction seems to occur even when newer COX inhibitors, such as Celebrex (celecoxib) and Vioxx (rofecoxib), are used. However, these newer agents don’t seem to cause kidney problems that can occur with older pain relievers, such as Voltaren, Motrin and Relafen.
