Children with localized scleroderma responded better to methotrexate than to prednisone in a small, placebo-controlled trial. “Although localized scleroderma is rather rare, it can be very aggressive and lead to complications in some patients,” Dr. Francesco Zulian said at the 17th Pediatric Rheumatology European Society Congress. “Some patients can have psychological sequelae as well, if the lesions occur on the face.”
