Research: 4-year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar and vaginal intraepithelial neoplasia and anogenital warts: Randomized controlled trial. Vaccination against certain types of human papillomavirus (HPV) gives strong and sustained protection against genital warts and pre-cancerous growths of the cervix, according to a new study published on bmj.com today.