A variation in a single gene is strongly associated with an increased risk of age-related macular degeneration (AMD), the leading cause of untreatable blindness in the elderly, according to a new study. Based on the finding, a simple test might be developed that could help identify people at risk for this condition, speculate researchers at the University of Pittsburgh. They believe that identification of the PLEKHA1 gene may also help researchers find more effective ways to prevent this ocular degeneration. In the September issue of the American Journal of Human Genetics, the researchers report that PLEKHA1 is involved in the cellular processes related to inflammation. This finding supports the hypothesis that inflammation plays a role in the damage caused by AMD.
