The global gene expression market size was USD 7.17 Billion in 2020 and is expected to register a CAGR of 7.6% during the forecast period.
The global gene expression market size was USD 7.17 Billion in 2020 and is expected to register a CAGR of 7.6% during the forecast period. Increasing advancements in genomics, rising prevalence of genetic diseases and cancer, technological developments in gene expression techniques, and availability of and access to comprehensive gene expression databases are key factors expected to drive market revenue growth over the forecast period. In addition, increasing focus on gene expression assays to detect and analyze rapidly emerging COVID-19 variants, growing need to streamline genetic analysis workflow, and rising drug discovery and development procedures are some other factors expected to boost revenue growth of the market to a significant extent going ahead.
Gene expression is a crucial life process through which gene sequences are transcribed into functional gene products such as functional RNAs or proteins. Gene expression plays an important role in functioning and development of an organism and provides a connection between gene-encoded information and a functional gene end-product. Gene expression is determined by deciphering the gene information during process of transcription and translation.
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Gene expression is very useful in identifying the molecular signature of a disease and for determining biomarker in correlation with dose dependent cellular responses on exposure to drug or therapeutic candidate. Gene expression offers crucial insights to efficiently guide drug discovery by demonstrating pathways of desired cellular pathways or networks. Gene expression signatures are also extensively employed in later stages of drug development based on their linkage to clinically important phenotypic characteristics. Over the recent past, increasing availability and affordability of DNA technologies has made gene expression indispensable in drug discovery and development. Gene expression is also being used in clinical diagnostics to optimize personalized medicine. This is expected to further contribute to revenue growth of the market over the forecast period.
Gene expression profiling can also detect comprehensive transcriptomic alterations in the target cells and tissues and therefore, is widely used to test the safety and efficacy of therapeutic agents under development such as small molecules, biologics, and small interfering RNAs. Gene expression can also be used to associate changes in animals with human clinical outcomes to identify disease biomarkers or treatment outcomes. These are some other key factors boosting adoption of gene expression and are expected to further fuel market growth. However, high costs associated with instrument and gene expression assays and lack of skilled professionals are some key factors that could hamper market growth over the forecast period.
Driver: Growing application of gene expression in drug discovery is a key factor driving market growth
Gene expression studies and assays have been widely used to determine the mechanisms of toxicity of drug and therapeutic candidates. Gene expression also helps in identifying desired drug effect in cancer cells and based on that post-treatment gene expression can be used to identify therapeutic candidates for their ability to induce the target phenotype in leukemia cells. Spectrometry-based gene expression method has been developed as a gene expression tool to understand the genomics of human cancer, effects of drug treatment, and basis of treatment failure. Gene expression also helps in redefining some diseases at molecular level and this has helped overcome several limitations of conventional drug discovery methods. Development of various gene expression profiles have accelerated every stage of drugs discovery process and has helped in identification of new drug targets, predict function of novel genes, and better understand individual variability in response to drug. These key factors are expected to significantly drive market revenue over the forecast period.
Restraint: Difficulties in translating results from animal models to humans is a key factor restraining market growth
One of the major challenges associated with gene expression is the complexity in translating results from animals to humans successfully. Since adequate interpretations of gene expression results in the context of biology and pharmacology are associated with accuracy of pre-established datasets, biological curation of gene expression signature from preclinical models has proven to be a massive challenge. Research carried out in human cell lines also potentially fail to translate in early human studies as limited number of cell lines cannot represent population-level outcome. In addition, difficulty in mapping changes observed in the cell lines or animal gene expression profiles to change in signature genes in human subjects has also hampered the adoption of gene expression. These are some major factors expected to hamper market growth to a certain extent over the forecast period. Shortage of skilled professionals, unavailability of standardized protocols, and high costs of equipment and assays are some other key factors expected restrain market growth.
Product & Services Outlook:
Based on product & services, the global gene expression market has been segmented into instrument, consumables, and services. Services segment is expected to register significant revenue growth over the forecast period attributed to increasing demand for robust gene expression profiling and bioinformatics services due to rising number of research and development activities. Gene expression services combine state-of-the-art methods and technologies and offer customized services to organizations and research institutes. Gene expression profiling is extremely useful in safety lead optimization and dose-limited toxicity studies and offer crucial insights that cannot be obtained through conventional methods. Key companies have started offering high-quality support and services at cost-effective prices and offer a wide range of RNA-seq profiling services to determine the presence and quantity of RNA for gene expression. Guarantee of complete sequence accuracy, shorter turnaround time, affordable prices, and skilled professionals have further boosted demand for best-in-industry gene expression services and is expected to contribute to revenue growth of the market going ahead.
Capacity Outlook:
Based on capacity, the global gene expression market has been segmented into low- to mid- plex gene expression analysis and high-plex gene expression analysis. High-Plex capacity segment is expected to account for largest revenue share over the forecast period owing to increasing adoption of gene expression analysis for the analysis of multiple genomic studies and rising introduction of high-throughput and fast solutions for multiplexed expression quantitation. Recent advancements in analysis techniques has enabled the measurement of secreted proteins and mRNA expression to offer a high-level of multiplexing to enhance and streamline the workflow of biomarker discovery. High-throughput multiplex gene analysis offers several benefits such as efficient results with minimal sample, conservation of reagents and materials, and increased capability for more comprehensive discovery exploratory experiments.
Increasing research and development activities have further led to development of superior solutions for high-level multiplexing of genomics and proteomics research. Development of digital spatial profiling for high-plex spatial profiling of proteins and RNA from various tissue samples has enabled researchers to view tissue samples in a new way by combining high-plex gene expression with spatial resolution. This has made the technique more accurate and precise and has emerged as a robust research tool for discovery of biomarkers and this is another key factor expected to drive revenue growth of this segment.
Application Outlook:
Based on application, the global gene expression market has been segmented into clinical diagnostics, drug discovery & development, biotechnology research, and others. Clinical diagnostic segment is expected to account for a significantly large revenue share over the forecast period. Increasing use of gene expression analysis for early and precise diagnosis of rare genetic disorders and chronic illnesses is a key factor expected to contribute to revenue share of this segment. Integration of bioinformatics and gene expression profiling have enhanced diagnostic platforms and monitoring of disease progression and therapeutic responses.
In clinical settings, to select accurate and better disease-specific therapeutic approaches a better understanding of clinical course of biologically defined disease subtypes is a prerequisite. For instance, comprehensive gene expression profiling can help in identification of new biologically defined and clinically relevant subtypes of leukemia as a basis for specific therapeutic decisions. This has led to increasing adoption of gene expression profiling in routine diagnostic applications and clinical trials. Gene expression profiling is currently used as a robust research tool but focus on increasing its number of potential clinical applications of are under development. Gene expression profile can provide prognostic information that addresses the aggressiveness of a tumor along with biomarkers that can trace disease prognosis and its response and outcome to therapies. These key factors are expected to expand the application of gene expression in clinical diagnostic and further drive revenue growth of this segment going ahead.
Regional Outlook:
Based on regional analysis, North America is expected to account for largest revenue share over the forecast period attributable to increasing investment to accelerate genomics and proteomics research, rising incidence of rare and chronic genetic disorders, growing research and development activities to develop new methods for gene expression analysis, and development of robust gene therapies for chronic illnesses. In addition, increasing number of clinical trials and presence of key market players in the region are some other key factors expected to fuel revenue growth of the North America market.
Asia Pacific is expected to register a steady revenue CAGR of 3% over the forecast period owing to increasing expenditure on developing robust research and healthcare facilities, rapid advancements in recombinant DNA technology and genomics, rising research studies in genomics and proteomics, availability of comprehensive database repositories, and increasing presence of key players in the region. In addition, increasing collaboration between key organizations to improve quality of healthcare and research infrastructure, availability of government funding for research activities, and growing application of gene expression profiling owing to increasing focus on personalized medicine are some other key factors expected to fuel revenue growth of the market in the region.
Competitive Landscape:
The global gene expression market is slightly fragmented with presence of several players operating on a global and regional scale. Key players are engaged in product development and strategic alliances to cater to growing global demand and gain a robust footing in the market. Major companies profiled in the market report include Agilent Technologies, QIAGEN N.V., Thermo Fisher Scientific, Inc., Illumina, Inc., Bio-Rad Laboratories, Inc., PerkinElmer Inc., Oxford Gene Technology, GE Healthcare, F. Hoffmann-La Roche AG, and Becton, Dickinson, and Company.
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Some Strategic Developments in the Market Include:
- In October 2021, biotech startup Immunai announced closing of a USD 125 million series B round of funding. Immunai has been building a comprehensive data set of clinical immunological information that combines genetic information and epigenetic changes or proteomics to understand how the immune system functions.
Pipeline Analysis:
A team of researchers from Alphabet’s Calico and Google’s DeepMind have partnered to introduce a neural network architecture called the Enformer. It is a transformers-based model with an enhanced capability of predicting gene expression from DNA sequences with greater accuracy. The model has been made public to accelerate the study of genes further and the model is expected to help researchers better understand variants in non-coding genome and predict the effects of any variants on gene expression. This can potentially help in deciphering the increasing number of disease-associated variations that are uncovered in genome-wide association studies.
Segments Covered in the Report:
This report offers historical data and forecasts revenue growth at a global, regional, and country level, and provides analysis of the market trends in each of the sub-segments from 2018 to 2030. For the purpose of this report, Reports and Data has segmented the global gene expression market based on product and services, capacity, application, and region:
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Gene Expression Market Report Scope
Segments covered By Product & Services Outlook, Capacity Outlook, Application Outlook, Regional Outlook
By Product & Services Outlook
Instrument
PCR
NGS
DNA Microarray
Others
Consumables
Reagents
DNA Chips
Services
Gene Expression Profiling Services
Sequencing Services
Other Services
Bioinformatics Solutions
By Capacity Outlook
Low- To Mid- Plex Gene Expression Analysis
High-Plex Gene Expression Analysis
By Application Outlook
Clinical Diagnostics
Drug Discovery & Development
Biotechnology Research
Others
Regional scope
North America
Europe
Asia Pacific
Latin America
Middle East & Africa
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