The global downstream processing market size is predicted to be worth around US$ 24.2 billion by 2030 from valued at US$ 6.8 Bn in 2020, expanding growth at a rapid pace from 2020 to 2030.
The global downstream processing market size is predicted to be worth around US$ 24.2 billion by 2030 from valued at US$ 6.8 Bn in 2020, expanding growth at a rapid pace from 2020 to 2030.
Report Highlights
- The chromatography systems segment dominated the market and accounted for the largest revenue share of 41.82% in 2021.
- The antibiotic production application segment dominated the market in 2021 and accounted for the largest share of more than 32.66% of the global revenue.
- The purification by chromatography segment dominated the global market and accounted for the largest revenue share of more than 41.05% in 2021.
- North America dominated the market and accounted for the largest revenue share of more than 34.63% in 2021.
- Asia Pacific, the market is expected to register the fastest growth rate from 2022 to 2030.
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Downstream processing is a series of events that is carried out in the pharmaceutical industry for the recovery and purification of the desired yield. These procedures play a vital role in biopharmaceutical production, as these procedures help companies to reach optimum levels of products at low cost of production.
Downstream processing involves several procedures such as cell separation, filtration, product recovery, product extraction, purification, and treatment of product by chemical, physical, and biological means. Downstream processing is an integral step in the production of various biological and pharmaceutical products such as vaccines, recombinant proteins/enzymes, antibiotics, antibodies, hormones, diagnostic enzymes, industrial enzymes, natural fragrance, and flavor compounds.
The expansion of the global downstream processing market can be attributed to rise in the demand for vaccines for COVID-19, introduction of new products and solutions for microbial fermentation, and continuous expansion of biopharmaceutical and biotechnology industries. However, limitations & constraints in producing humanized peptides and stringent rules and regulations for validating filtration products are likely to restrain the downstream processing market in the short-term.
Products Insights
The chromatography systems segment dominated the market and accounted for the largest revenue share of 41.82% in 2021. Continuous R&D activities to improve the efficiency and speed of chromatography systems are anticipated to propel segment growth. In April 2021, Thermo Fisher Scientific launched the HyPeak chromatography system, it is the company’s only single-use chromatography system for bioprocessing, with significant functions in therapeutic protein as well as vaccine development. A rise in the deals and developments pertaining to chromatography systems also facilitates segment growth. For instance, in January 2021, Sartorius Stedim Biotech announced acquiring the chromatography equipment business from Novasep.
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This will assist Sartorius to develop novel chromatography systems, which, in turn, will overcome efficiency issues and bottlenecks in downstream processing. The filters segment is expected to register the fastest CAGR from 2022 to 2030. A rise in the utility of filters for viral inactivation is the key factor driving the market for downstream processing. In September 2020, a team of researchers from the Pennsylvania State University analyzed the efficiency of BioEX hollow fiber and Planova 20N virus filters for the removal of viral-size particles. Such studies are anticipated to increase the adoption rate of filters for downstream processing of biologics.
Application Insights
On the basis of applications, the global market has been further categorized into antibiotic production, hormone production, antibody production, enzyme production, and vaccine production. The antibiotic production application segment dominated the market in 2021 and accounted for the largest share of more than 32.66% of the global revenue. This high growth can be attributed to the wide application scope of antibiotics for the treatment of several disorders. More than 700,000 people die of antibiotic-resistant bacteria, annually. This leads to the high demand for the development of antibiotics, which in turn propels market growth.
Antibodies production grew at the fastest rate owing to the rise in demand for monoclonal antibodies. The launch of novel products for efficient purification of antibodies also propels segment growth. For instance, in January 2021, Cytiva launched HiScreen Fibro PrismA for the process development and purification of monoclonal antibodies (mAb). The product features a fiber-based Protein A platform which enables a 20-fold increase in productivity.
Technique Insights
The purification by chromatography segment dominated the global market and accounted for the largest revenue share of more than 41.05% in 2021. Single-use chromatography and filtration systems are considered the gold standards in downstream bioprocessing, hence companies are engaging in business development strategies, such as acquisition, merger, and agreement, for expanding their chromatography portfolio. For instance, in December 2021, Repligen bought Newton, New Jersey-based BioFlex Solutions. The purchase adds to and enhances Repligen’s single-use fluid management product line, as well as simplifies its supply chain. The integration of BioFlex Solutions strengthens its system offering by further integrating components and assemblies.
In August 2021, Danaher Corp. completed the acquisition of Aldevron. Aldevron will function as a separate operational business and brand inside Danaher's Life Sciences sector. The solid-liquid separation segment is expected to witness the highest CAGR during the forecast period. There are several advantages of solid-liquid separation, such as it is simple, cost-effective, and well suited for continuous-mode manufacturing. However, high shear forces generated are a common hurdle with this technique. Therefore, to cope with these problems, recent developments, such as depth filters including multistage depth filtration, alternating tangential flow microfiltration, and tangential flow filtration methods, are being adopted for high cell density processes.
Regional Insights
North America dominated the market and accounted for the largest revenue share of more than 34.63% in 2021 owing to government support promoting bioprocess technologies, rising medical expenditure, and developed healthcare infrastructure. In addition, the region has witnessed major collaborative activities with healthcare giants that are extensively investing in the R&D of biopharmaceuticals and vaccines. In addition, key players operating in the market are expanding their foothold in this region. For instance, Thermo Fisher Scientific Inc. recently announced a USD 97 million investment to extend its clinical research facilities in Richmond, Virginia.
The facilities, which comprise laboratory operations obtained with the acquisition of PPD, Inc. in December 2021, will meet the growing need for consistent, greater laboratory services in biopharma to advance drug development. In Asia Pacific, the market is expected to register the fastest growth rate from 2022 to 2030 due to the rising investments by developers and consumers in the field of biotechnology. The presence of a large population base is driving the need for advanced medical facilities for which, players are keen on implementing rapid analytical methods to support in-process designing and bioprocessing.
China dominated the regional market of the Asia Pacific owing to the growing biopharmaceutical industry and high demand for medicines & vaccines. The biopharmaceutical industry is amongst the most active economic sectors in China and is marked by continuous revolution with modern biopharmaceutical equipment and process. For instance, in April 2021, Asahi Kasei Corp., a solution supplier to the biologics manufacturing sector, extended its operations in China with the establishment of Asahi Kasei Bioprocess Co., Ltd. By localizing inventory management and order processing for faster delivery periods, the introduction of AKBC facilitates company development in China.
Key Players
The global downstream processing market is consolidated in terms of number of players. A few number of players account for significant share of the global market. Key players operating in the global downstream processing market include Danaher Corporation, Merck KGaA, Sartoris Stedim Biotech S.A., Thermo Fisher Scientific Inc., 3M Company, Lonza Group, Eppendorf AG, and Boehringer Ingelheim International GmbH.
Market Segmentation
By Technique
- Purification
- Solid-Liquid Separation
- Clarification/Concentration
By Product
- Chromatography Columns & Resins
- Filters
- Membrane Absorbers
- Single-use product
- Polypropylene
- Others
By Application
- Monoclonal Antibody Production
- Vaccine Production
- Insulin Production
- Immunoglobulin Production
- Erythropoietin Production
- Others
By End User
- Biopharmaceutical Manufacturers
- Contract Research Organizations
By Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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