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Downstream Processing Market Size - Quantitative Research By QYResearch Medical

November 15, 2022 | 
9 min read

The global downstream processing market is forecasted to grow at a rate of 12.7%, from USD 18.22 billion in 2019 to USD 45.49 billion in 2030.

The global downstream processing market is forecasted to grow at a rate of 12.7%, from USD 18.22 billion in 2019 to USD 45.49 billion in 2030. The market for Downstream Processing is anticipated to expand significantly over the forecast period due to the growing demand for biopharmaceuticals. Besides, the biotechnology industry’s exponential expansion is expected further to propel the market growth in the forecasted timeline. In order to develop a safe, clean and economical method for every bio-project, downstream processing plays an essential role. In biotechnology, downstream processing concerns the isolation and purification of the bio-product downstream of the fermenter.

The increase in biologic infiltration and biological macromolecules is also anticipated to augment downstream processing demand during the forecasted period. Furthermore, a significant rise in demand for recombinant and drug-quality is forecasted to stimulate market growth to a certain extent. At present, recombinant DNA technology is used primarily for the processing of biopharmaceutical products, where cleaning is carried out by integrating membrane, filtration, and chromatography. In the downstream processing of recombinant proteins, a variety of chromatographic steps are involved.

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However, the lack of single-use options and purification bottlenecks, and the high cost of instruments are anticipated to hinder the market growth over the forecasted timeframe.

Product Outlook:

In the forecasted timeframe, the downstream processing market is expected to be dominated by the chromatography segment with a CAGR of 13.0%. The major market players have comprehensive and stable strategies that function effectively across the essential phases of process development. The design of single-use chromatography, which is deemed an essential innovation in the field of bio-pharmacy and is estimated to see significant growth during the forecast timeline, also resulting in technical developments.

Method Outlook:

Purifying by Chromatography segment is anticipated to hold the largest market over the forecasted period. The Purifying by Chromatography segment is expected to worth USD 19.61 billion by 2030, with a higher CAGR of 12.8%. In isolation and purifying of the high-quality products, chromatography by separation has been used. It is the main phase method that can be used before the late stages of purifying at a certain stage of downstream processing.

Application Outlook:

In the forecast period, the Development of Antibiotics was the largest market. Antibiotics are utilized to manage a host of illnesses that range from infections to bacterial infections. One of the most widely marketed commercialized drugs globally is a β-lactam antibiotic, particularly ketoconazole and penicillin. Organic cephalosporin and penicillin are developed by biorefinery technologies on an industrial level and are obtained by downstream processing.

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End-User Outlook:

The biopharmaceutical manufacturers segment is forecasted to hold the largest market. It is also expected that the biopharmaceutical manufacturers segment will experience the highest CAGR over the prediction. The second half of a traditional biopharmaceutical production phase is generally considered to be downstream processing.

Regional Outlook:

Due to government funding for the adoption of bioprocess technology, substantial growth in medical spending, and the availability of strong healthcare facilities, the North American region led the downstream processing industry with the highest market over the projected period. Significant joint efforts have also been observed in the area and the domination of a few of the healthcare companies that are bringing significant investments in the research and development of biotech and vaccinations.

Market-O-Nomics

  • Over the forecast period, the filtration segment is expected to register the fastest CAGR in the downstream processing market. The demands for innovative separation and purification methodologies have been removed by filtration and are extremely crucial for infectious protection as a pathogen can significantly affect the whole procedure. Additionally, technical developments in single-use filtration technologies are forecasted to increase the expansion of the segment.
  • Over the projected timeframe, the segment of antibodies is forecasted to experience the fastest CAGR in the downstream processing market. This is attributable to the development of reliable platforms in mammal cultures to produce higher antibody titer for monoclonal antibodies. Moreover, the emergence of new techniques like non-chromatographic isolation and alternate mechanisms of expression for the bio-production of antibodies has contributed to the advancement of techniques to process mechanisms.
  • During the forecast period, Europe is anticipated to account for the second-largest market with a CAGR of 12.8%. The demand for advanced bioproduction technologies in this region has been reinforced by rising quality standards.

Companies considered and profiled in this market study.

GE Healthcare, Danaher Corporation, Sartorius Stedim Biotech S.A., Merck KGaA, 3M, Lonza Group AG, Repligen Corporation, Eppendorf AG, Thermo Fisher Scientific Inc., and Corning Incorporated, has been profiled in the report. They are significant manufacturers of Downstream Processing solutions.

The players operating in the market have undertaken several strategies related to the market in the period 2018-2020. The key highlight is:

  • In November 2020, an innovative artificial intelligence (AI) algorithm has been declared by GE Healthcare to assist health professionals in assessing Endotracheal Tube (ETT) placements, a crucial and essential process while ventilating patients with severely ill Covid-19. The AI system is among those integrated into the Critical Care Suite 2.0 from GE Healthcare, an industry-first series of AI algorithms for automatic assessments, case prioritization, and quality management implemented on a handheld x-ray device. This initiative will improve its position in recent times to combat covid-19.

Start-up Traction

The industry offers numerous growth opportunities. Thus, a number of startups providing innovative solutions and technologies have been entering the market. As the market is witnessing the infiltration of technology, several new startup companies are trying to infiltrate the market. One such startup is Artesyn Biosolutions Ireland Ltd. ARTeSYN Biosolutions, a privately owned firm, is a quickly growing brand that provides the biotechnology & cell and gene therapy industry with single-use solutions. The company has USD 3.0 Million in total revenue.

Deals Landscape

Mergers and Acquisitions are an integral part of the Downstream Processing industry. Along with the companies operating in the market, other key market players have also been entering the industry.

  • In October 2020, ARTeSYN Biosolutions acquired by Repligen Corporation. For chromatography, filtration, continuous manufacturing, and media/buffer prep workflows, ARTeSYN offers single-use solutions. Along with the latest acquisitions of Engineered Molding Technologies and Non-Metallic Solutions, the ARTeSYN collaboration will enhance the capabilities of Repligen in single-use systems and related integrated flow path assembly.

Expert Insights:

Reports and data predict encouraging advances to accelerate the use of Downstream Processing. According to industry analysts, new companies enter the market, which may theoretically change the situation. New entrants that enter the market must concentrate on innovating and integrating through new technologies while reducing complexity and lowering total operational costs. Experts also believe that increasing the implementation of emerging technology in developed nations would be a critical growth field for the industry. Company strategy review shows that most businesses concentrate on product launch, as well as negotiations to increase their share and scale. Both approaches contributed to the advancement of the technologies and product diversification in the untapped regions. The businesses implemented these approaches to diversify their business within the industries

Segments Covered in the report

This report forecasts revenue growth at a global, regional & country level and provides an analysis of the market trends in each of the sub-segments from 2018 to 2030. The scope of the report can be defined as:

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For the purpose of this report, Reports and Data has segmented into the Global Downstream Processing Market on the basis of product, method, application, end-user, and region:

Product Outlook (Revenue, USD Billion; 2017-2030)

  • Evaporators
  • Dryers
  • Chromatography
  • Centrifuges
  • Filters
  • Others

Method Outlook (Revenue, USD Billion; 2017-2030)

  • Purifying by Chromatography
  • Disruption of Cells
  • Concentration
    • Membrane filtration
    • Evaporation
  • Formulation
  • Solid-liquid Separation
    • Centrifugation
    • Filtration

Application Outlook (Revenue, USD Billion; 2017-2030)

  • Enzyme Synthesis
  • Production of Hormones
  • Producing antibodies
  • Development of Antibiotics
  • Making Vaccinations

End-User Outlook (Revenue, USD Billion; 2017-2030)

  • Contract Manufacturing Organizations
  • Biopharmaceutical Manufacturers

Regional Outlook (Revenue, USD Billion; 2017-2030)

  • North America
    • U.S
    • Canada
  • Europe
    • Germany
    • U.K
    • France
    • BENELUX
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • South Korea
    • Rest of APAC
  • MEA
    • Saudi Arabia
    • UAE
    • Rest of MEA
  • Latin America
    • Brazil
    • Rest of LATAM

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