CAMBRIDGE, Mass.--(BUSINESS WIRE)--DecImmune Therapeutics today announced that it has been awarded a $3 million, three-year Phase II SBIR grant to support late preclinical studies and initial clinical trials of DeciMab™, its novel monoclonal therapeutic in development for the treatment of the vascular inflammatory diseases. With this grant, DecImmune has now been awarded $7 million in SBIR funding to accelerate DeciMab’s development.
DeciMab targets a novel innate autoimmune pathway that arises in large and small vessels following a wide range of insults including hyperglycemia, ischemia in sickle cell disease and heart attacks, and in chemotherapeutic cardiotoxicities. If not checked at the outset by DeciMab, localized inflammation can lead to tissue scarring that permanently compromises organ function. DecImmune has demonstrated preclinical proof-of-concept with DeciMab, showing in small and large animals that a single dose of DeciMab immediately following a heart attack prevents significant cardiac tissue damage and enables pumping efficiency to continue at near normal levels three weeks later. The grant announced today is supporting continued development for the prevention of heart failure post heart attack.
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DeciMab targets a novel innate autoimmune pathway that arises in large and small vessels following a wide range of insults including hyperglycemia, ischemia in sickle cell disease and heart attacks, and in chemotherapeutic cardiotoxicities. If not checked at the outset by DeciMab, localized inflammation can lead to tissue scarring that permanently compromises organ function. DecImmune has demonstrated preclinical proof-of-concept with DeciMab, showing in small and large animals that a single dose of DeciMab immediately following a heart attack prevents significant cardiac tissue damage and enables pumping efficiency to continue at near normal levels three weeks later. The grant announced today is supporting continued development for the prevention of heart failure post heart attack.
Help employers find you! Check out all the jobs and post your resume.
