According to Vision Research Reports, the global cell separation market size was valued at USD 9.08 billion in 2023 and it is increasing up to USD 23.49 billion by 2033 with a CAGR of 9.97% from 2024 to 2033.
According to Vision Research Reports, the global cell separation market size was valued at USD 9.08 billion in 2023 and it is increasing up to USD 23.49 billion by 2033 with a CAGR of 9.97% from 2024 to 2033.
The cell separation market refers to the industry involved in the separation and isolation of specific cells or cell populations from complex biological samples. This process allows researchers, clinicians, and biopharmaceutical companies to study and manipulate individual cell types for various applications such as cell therapy, diagnostics, drug discovery, and research. Cell separation techniques can utilize physical, chemical, or biological methods to selectively isolate target cells based on their size, density, surface markers, or other distinguishing characteristics. The cell separation market encompasses a wide range of products and technologies including centrifugation, flow cytometry, magnetic-activated cell sorting (MACS), and microfluidics, among others.
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Key Pointers
- North America held the dominant position in the market, commanding the largest market share of 40% in 2023.
- The Asia Pacific region is projected to witness the highest compound annual growth rate (CAGR) of 15.66% from 2024 to 2033.
- In terms of product segmentation, the consumables segment accounted for the highest market share of 62% in 2023.
- Among different cell types, the animal cells segment emerged as the leader, contributing 54% of the market share in 2023.
- Looking ahead, the human cell segment is anticipated to experience the highest CAGR of 12.47% from 2024 to 2033.
- Within the techniques utilized, the centrifugation segment held the largest market share of 43% in 2023.
- As for applications, the biomolecule isolation segment captured the highest market share of 30% in 2023.
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Cell separation is a process of isolating one or more specific cell populations from a heterogeneous mixture of cells. This is important for a variety of applications, including:
- Stem cell research: Cell separation is used to isolate stem cells from tissues such as bone marrow and blood. Stem cells have the potential to develop into many different types of cells, which makes them valuable for research into regenerative medicine.
- Tissue regeneration: Cell separation can be used to isolate specific cell types that can be used to regenerate damaged tissues. For example, this technique is being used to develop new treatments for conditions such as heart disease and Parkinson's disease.
- In vitro diagnostics: Cell separation is used to isolate specific cell types for diagnostic purposes. For example, this technique can be used to isolate cancer cells from a blood sample.
- Biomolecule isolation: Cell separation can be used to isolate specific biomolecules from cells, such as proteins and DNA. These biomolecules can be used for a variety of research and diagnostic purposes.
- Cancer research: Cell separation plays a pivotal role in isolating and analyzing specific cancer cell populations. This facilitates research on tumor biology, drug development, and personalized cancer therapies.
Cell Separation Market Growth Factors
- Rising Incidence of Chronic Diseases: The growing prevalence of chronic diseases such as cancer, autoimmune disorders, and infectious diseases fuels the need for advanced diagnostic and therapeutic approaches. Cell separation technologies play a crucial role in understanding disease mechanisms, developing targeted therapies, and monitoring treatment responses.
- Advancements in Cell Therapy: The rapid development of cell-based therapies, including CAR-T cell therapy, mesenchymal stem cell therapy, and tissue engineering, drives the demand for precise cell isolation techniques. Cell separation enables the purification and expansion of therapeutic cell populations for clinical applications.
- Increasing Investments in Biotechnology and Healthcare: Rising investments in biotechnology research, healthcare infrastructure, and life sciences funding support the development and commercialization of novel cell separation products and technologies. Funding initiatives from governments, private investors, and philanthropic organizations propel market growth and innovation.
- Growing Demand for Personalized Medicine: The shift towards personalized medicine, characterized by tailored diagnostic and therapeutic approaches based on individual patient characteristics, drives the demand for precise cell isolation techniques. Cell separation enables the identification of biomarkers, patient stratification, and the development of personalized treatment strategies.
- Expanding Applications in Drug Discovery and Development: Cell separation technologies play a crucial role in drug discovery and development processes, including target identification, lead optimization, and toxicity screening. The increasing adoption of cell-based assays and high-content screening techniques in pharmaceutical research drives the demand for advanced cell separation platforms.
- Rising Geriatric Population: The aging population worldwide contributes to the increasing prevalence of age-related diseases and conditions, driving the demand for innovative healthcare solutions. Cell separation technologies support research efforts aimed at understanding aging-related mechanisms, developing regenerative therapies, and improving healthcare outcomes for elderly patients.
There are a number of different techniques that can be used for cell separation. The most common techniques include:
- Centrifugation: Centrifugation is a technique that uses centrifugal force to separate cells based on their size and density.
- Surface marker sorting: Surface marker sorting is a technique that uses antibodies to identify and isolate cells based on the presence of specific proteins on their surface.
- Filtration: Filtration is a technique that uses filters to separate cells based on their size.
Product Insights
In 2023, the consumables segment emerged as the dominant force in the market, capturing the largest revenue share at 62%. This segment's stronghold was primarily attributed to frequent purchases of consumables. Moreover, heightened investments in research and development by pharmaceutical and biopharmaceutical firms, particularly for the advancement of cutting-edge biologics like monoclonal antibodies and vaccines, propelled the growth of this segment.
Technological advancements in instruments are enabling more efficient cell separation in research, diagnostics, and therapeutic applications. Consequently, the instruments industry is 9 in the forecast period. Nonetheless, the high cost associated with instruments is projected to somewhat impede market expansion. To gain a competitive edge, companies are increasingly focusing on developing sustainable technologies. For example, in March 2022, Element Biosciences unveiled details about its upcoming Aviti DNA sequences.
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Cell Type Insights
In 2023, the animal cells segment claimed the largest revenue share, accounting for 54% of the market. This significant share was propelled by the increasing focus of governmental bodies, private enterprises, and healthcare institutions on the exploration and development of new drugs. Animal cells play a pivotal role in drug discovery and development processes, serving to evaluate the efficacy, pharmacokinetics, and initial toxicity of emerging drug compounds.
Meanwhile, the human cell segment is projected to demonstrate the most rapid growth rate, anticipated at 12.47% from 2024 to 2033. This surge is attributed to heightened attention towards human and cancer research, coupled with the diverse applications of isolated human cells in biopharmaceutical advancements, clinical trials, and scientific investigations. Additionally, favorable reimbursement policies associated with personalized medicine initiatives in developed nations are fostering increased demand for human cell isolation technologies.
Technique Insights
In 2023, the centrifugation segment emerged as the market leader, commanding a substantial revenue share of 43%. This dominance can be attributed to the widespread adoption of centrifugation techniques across academic institutions, research laboratories, and the biotechnology and biopharmaceutical sectors. Centrifugation stands as a cornerstone process in various applications, with density gradient centrifugation and differential centrifugation emerging as the most commonly employed methods for cell isolation and separation.
Meanwhile, the surface marker technique is poised to experience the fastest growth rate, projected at 12.38% from 2024 to 2033. This notable expansion is fueled by increased investments in manufacturing infrastructure by industry players, coupled with advancements in product development. Manufacturers are actively leveraging advanced surface markers in their production processes to ensure enhanced quality of the final products.
Application Insights
In 2023, the biomolecule isolation segment emerged as the market leader, commanding a significant share of 30%. This segment exhibited robust growth momentum and is expected to maintain its position as the fastest-growing segment, with a projected compound annual growth rate (CAGR) of 11.44% from 2024 to 2033. The predominant factor driving its prominence is the increasing emphasis on the production of biopharmaceuticals, including biosimilars, monoclonal antibodies, and recombinant proteins. Moreover, heightened government funding for new drug development initiatives further propels market expansion.
Concurrently, the cancer research segment is forecasted to experience lucrative growth, with a projected CAGR of 10.17% from 2024 to 2033. This growth can be attributed to rising investments in cell-based research by both companies and research laboratories. Several public-private partnerships are channeling substantial investments into cancer research, driven by the escalating global incidence of cancer, thereby stimulating demand for innovative cell separation solutions.
End-use Insights
In 2023, the segment comprising biotechnology and biopharmaceutical companies emerged as the market leader, capturing a significant revenue share of 43%. This segment is poised to maintain its dominance throughout the study period. These companies are deeply engaged in extensive research and development (R&D) endeavors aimed at pioneering new-generation therapeutics, which necessitate the utilization of advanced cell separation techniques. Additionally, the escalating research activities undertaken by commercial entities to develop efficient vaccines and therapeutics for COVID-19 are anticipated to fuel substantial demand for cell separation solutions, thereby fostering continued growth within this segment.
Meanwhile, the segment encompassing research laboratories and institutes is forecasted to demonstrate steady growth, with an estimated compound annual growth rate (CAGR) of 9.28% from 2024 to 2033. This growth trajectory can be attributed to the increasing R&D initiatives spearheaded by research institutions, particularly in the fields of oncology and neuroscience, aimed at the development of novel therapies. Furthermore, the proliferation of research institutes and laboratories worldwide is expected to serve as a key driver of segment expansion. For instance, in April 2022, Curate Biosciences forged a collaboration with the City of Hope, a prominent cancer research and treatment organization in the U.S., to evaluate the efficacy of its Curate Cell Processing System.
Regional Insights
In 2023, North America emerged as the dominant force in the global market, commanding the largest revenue share at 40%. This prominence can be attributed to several factors, including the presence of well-established pharmaceutical and biotechnology industries, particularly in the United States. The region also exhibits a high adoption rate of technologically advanced solutions, further bolstering its market position. Moreover, the extensive research activities conducted by research universities in North America, particularly in the field of cell therapies, have spurred significant demand for cell separation solutions.
Conversely, Asia Pacific is forecasted to experience the fastest growth, with a projected growth rate of 15.66% from 2024 to 2033. This rapid expansion is driven by the burgeoning pharmaceutical and biotechnology industries in emerging economies such as China and India. Additionally, the region's growth is fueled by increased healthcare expenditure and the expanding market penetration of major global players in key Asia Pacific countries. Furthermore, ongoing initiatives in stem cell and gene therapy research in countries like Japan, China, and South Korea have further propelled the demand for cell separation solutions in the region.
Cell Separation Market Key Companies
- Thermo Fisher Scientific, Inc.
- BD
- Danaher
- Terumo Corp.
- STEMCELL Technologies Inc.
- Bio-Rad Laboratories, Inc.
- Merck KGaA
- Agilent Technologies, Inc.
- Corning Inc.
- Akadeum Life Sciences
Recent Developments
- In March 2022, an infrastructure network was established at seven university hospitals in North Rhine-Westphalia (NRW) to conduct innovative cell therapies against COVID-19 and potential viral pandemics. The University Hospital of Cologne is investigating the use of COVID-19 cell therapy as part of this initiative. The funding of 7.75 million euros for these innovation initiatives is provided by the North Rhine-Westphalia Ministry for Economic Affairs, Innovation, Digitalization, and Energy.
- In February 2021, Propel Labs, based in the United States, sold its cell-sorting assets to Thermo Fisher Scientific. As per the agreement, Thermo Fisher Scientific acquired Propel Labs' innovative Bigfoot Spectral Cell Sorter along with approximately 40 personnel, thereby enhancing its capabilities.
- In October 2021, PerkinElmer, Inc. announced the commercial launch of the HIVE scRNAseq Solution for single-cell isolation and analysis in partnership with Honeycomb Biotechnologies, Inc. Additionally, Thermo Fisher Scientific Inc. acquired the Bigfoot Spectral Cell Sorter from Propel Labs in February 2021 to expand its sorting capabilities, improve safety features, and increase throughput.
Cell Separation Market Segmentations:
By Product
- Consumables
- Reagents, Kits, Media, and Sera
- Beads
- Disposables
- Instruments
- Centrifuges
- Flow Cytometers
- Filtration Systems
- Magnetic-activated Cell Separator Systems
By Cell Type
- Human Cells
- Animal Cells
By Technique
- Centrifugation
- Surface Marker
- Filtration
By Application
- Biomolecule Isolation
- Cancer Research
- Stem Cell Research
- Tissue Regeneration
- In Vitro Diagnostics
- Therapeutics
By End-Use
- Research laboratories and institutes
- Biotechnology and biopharmaceutical companies
- Hospitals and diagnostic laboratories
- Cell banks
By Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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