SplicingCodes, BioTailor Inc announced that a human individual encodes at least a thousand hereditary fusion genes, contributing to an estimated 85% of the total human inheritance variances.
SplicingCodes, BioTailor Inc announced that a human individual encodes at least a thousand hereditary fusion genes, contributing to an estimated 85% of the total human inheritance variances. To reduce confusion, scientists have classified the fusion genes into somatic, epigenetic (read-through), and hereditary fusion genes. This discovery is the first to demonstrate that hereditary fusion genes, not single nucleotide variants, are the most dominant genetic factors and will fundamentally reshape human genetics and biology. In contrast to traditional gene mutations under direct natural selections, hereditary fusion genes generated from DNA duplications and amplifications are under their parents' protection. They have time to be accumulated in a population and possess much higher recurrent frequencies than the somatic fusion genes. This finding means that majorities of human hereditary fusion genes evolve in “hidden” modes to adapt to their environments without significantly reducing inheritability. Gene duplications are classical genetic biomarkers and provide the most crucial self-supported evidence for the concept of hereditary fusion genes. The paper titled “The First Glimpse of Homo sapiens Hereditary Fusion Genes” has been published in the Journal of Pharmacogenomics & Pharmacoproteomics (DOI: 10.35248/2153-0645.22.13.016).
The discovery of hereditary fusion genes as potential dominant inheritance biomarkers will profoundly affect future human genetics and biology. First, we have significantly underestimated human inheritance. Genetics are everywhere, from diseases and behaviors which can be affected by environments and time. Suppose you have not found any inheritance factors or only several single nucleotide variants (SNPs) associated with a complex trait or disease. It would be best if you gave hereditary fusion genes a try. Second, classifying fusion genes into three groups will significantly reduce the cost of discovering them and dramatically increase accuracy. Third, epigenetic fusion genes reflect developmentally interactive consequences between genetics and environments. Finally, breakthroughs in theories and technologies will likely lead to rapid advances in diagnosing and preventing human diseases, from cancer to Alzheimer’s.
About SpicingCodes and BioTailor: They have been initially established to promote the splicingcodes theory that both 5'-exonic and 3'-intronic sequences determine the pre-mRNA splicing specificity. Misunderstandings have led us to transform splicingcodes theory into technologies, one of which is the most straightforward algorithm for identifying fusion genes. However, experimental validations have shown that our fusion gene data do not fit any scientific models and assumptions of genetics and biology. It has taken us years to reexamine every procedure and data and systematically develop strategies and approaches to study hereditary fusion genes. Results reported in a conference meeting abstract and private family history from a cancer-fighting pioneer have removed the last remaining self-doubts about human hereditary fusion genes. These honest scientists, doctors, and pioneers deserve our utmost respect.
For support: If you are interested in studying the hereditary and epigenetic fusion genes and require technological and scientific supports, please get in touch with us via support@splicingcodes.com.
For Investors: Serious inquiry, please. Dr. Degen Zhuo: degen.zhuo@gmail.com.
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