Compugen Ltd. Provides Update On COM701 And Upcoming Presentations
Published: May 31, 2017
Israel, May 31, 2017
Compugen Ltd. (NASDAQ: CGEN), a therapeutic discovery company, announced today that it anticipates a delay of several months in the submission of an investigational new drug application (IND) for COM701, Compugen's clinical candidate antibody targeting CGEN-15029/PVRIG. Previously the Company had disclosed an expectation of IND filing in Q4 of this year.
The Company was recently informed by its manufacturing service provider for COM701 - a global contract development and manufacturing organization (CDMO) - that the batch of material they manufactured for Compugen's planned GLP (good laboratory practice) toxicity studies was contaminated during the manufacturing process. The contamination was discovered during quality control procedures prior to release of the affected batch and, as such, was not used in any preclinical studies. This contamination has necessitated the production of a new batch of material for the execution of these studies. As a result, Compugen anticipates a delay of several months in the submission of an investigational new drug application (IND) for COM701 and will provide further updates as appropriate.
Anat Cohen-Dayag, PhD, CEO and President of Compugen, commented, "As previously disclosed, the COM701 program is one of the four program areas that are currently the focus of the Company's therapeutics and business development efforts. While we are disappointed in the delay of our anticipated IND filing date, we would like to stress that this contamination and resulting delay are related to a technical issue in the CDMO's manufacturing process, and does not detract from the quality of the data generated by the Company supporting the clinical rationale for COM701. Therefore, based on the information currently available to us, we expect this delay may have a limited effect with respect to our on-going business development discussions for this program."
As previously announced, new data on COM701 will be presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Illinois next week. Compugen's poster presentation at ASCO will take place on Monday, June 5 at 8:00-11:30am CT (Abstract 3074, location: Hall A). The following day, Tuesday, June 6 at 2:00 pm ET, Dr. Cohen-Dayag will present at the Jefferies Global Healthcare Conference. A live webcast and slide presentation of the Jefferies talk will be available on the Company's website.
Compugen is a leading therapeutic discovery company whose mission is to utilize its broadly applicable predictive discovery infrastructure to discover novel drug targets and develop first-in-class therapeutics. Our current pipeline consists of early and preclinical stage immuno-oncology programs based on novel drug targets discovered internally, primarily immune checkpoint and myeloid protein target candidates. These programs focus on the development of first-in-class cancer immunotherapy drugs with the potential to harness the immune system to provide treatment solutions in areas of unmet medical need in various cancer types and patient populations, both as monotherapy and in combination with other drugs. In addition, our pipeline currently includes a preclinical fusion protein autoimmune product candidate. Compugen's business model is based on selectively entering into collaborations for its novel target candidates and related drug product candidates at various stages of research and development under
revenue-sharing agreements. The Company is headquartered in Israel, with R&D facilities in Israel and South San Francisco. At the US facilities, therapeutic monoclonal antibodies are discovered and developed against the Company's novel drug target candidates. For additional information, please visit Compugen's corporate website at http://www.cgen.com.