Advanced glycation end products (AGEs) are a group of compounds that are usually developed via non-enzymatic reactions which occur between the carbonyl groups of reducing sugars & the free lipids, amino groups of proteins, or nucleic acids.
Advanced Glycation End Products Market: Introduction
- Advanced glycation end products (AGEs) are a group of compounds that are usually developed via non-enzymatic reactions which occur between the carbonyl groups of reducing sugars & the free lipids, amino groups of proteins, or nucleic acids. They could be derived exogenously from diet or by endogenously inside the body. Advanced glycation end products form intracellularly and extracellularly inside every tissues and body fluids and are capable of cross-linking with other proteins, which can affect their normal mechanism or functions.
- The advanced glycation end products market can be segmented based on type, indication, end-user, and region. Based on type, the market can be categorized into non-fluorescent AGEs, fluorescent AGEs, and others. The fluorescent AGEs segment can be further sub-segmented into Pentosidine and Methylglyoxal-lysine dimer (MOLD). The non-fluorescent AGEs segment can be further split into Carboxymethyl-lysine (CML), Carboxyethyl-lysine (CEL), and Pyrraline. Based on end-user, the market can be classified into hospitals, homecare, specialty clinics, and others. In terms of indication, the market can be further categorized into diabetes, neoplasm, orthopedic disorder, neurodegenerative disorder, and others.
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Key Drivers, Restraints, and Opportunities of Global Advanced Glycation End Products Market
- Rise in incidence of cancer globally is driving the market, as advanced glycation end products majorly raise the level of inflammation in the body, which has been associated with the development of cancer. For instance, according to the National Cancer Institute, 2019, an estimated 1,762,450 new cases of cancer were diagnosed, globally, with around 606,880 deaths from the disease.
- Rising incidences of neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases, is anticipated to fuel the market during the forecast period, as advanced glycation end products are proteins that get glycated after the exposure to sugars, which further contributes to the development of neurodegenerative disorders.
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- Higher cost of esthetic procedures is estimated to hamper the market during the forecast period. As per the American Society of Plastic Surgeons, the average cost of botox treatment is around US$ 397 in the U.S., while a single session of microdermabrasion costs approximately US$ 131 and the cost of a chemical peel is around US$ 669.
- Advanced glycation end products (AGEs) are obtained by the fixing of sugars on proteins, creation of cross links, which tentatively minimize the elasticity of elastin used in esthetic procedures. The American Society of Plastic Surgeons has suggested to postpone all elective services; consequently, numerous esthetic procedures including botulinum toxin therapy, chemical peel, and dermabrasion have decreased, thereby restraining the advanced glycation end products market.
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North America to Capture Major Share of Global Advanced Glycation End Products Market
- North America is anticipated to be a highly lucrative market for advanced glycation end products owing to the presence of prominent biopharmaceutical players in the region. Rapid approval of biopharmaceutical products by regulatory agencies is also fueling the advanced glycation end products market in the region.
- However, the market in Asia Pacific is estimated to expand at a rapid pace owing to the presence of significant generic manufacturers and focus of major players on the region. Expansion of pharmaceutical and biopharmaceutical industries has led to the rapid demand for advanced glycation end products in the region. Additionally, investments by Contract Research Organizations (CROs) for the development of drugs and biologics are anticipated to drive the advanced glycation end products market in Asia Pacific.
- The market in Latin America is projected to expand at a steady pace owing to the presence of rapidly developing economies along with enhanced healthcare infrastructure in the region. The market in Brazil is anticipated to expand at a significant growth rate during the forecast period due to the rising life science-regarding research and development of healthcare infrastructure in the country.
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Key Players Operating in Global Advanced Glycation End Products Market
The global advanced glycation end products market is highly fragmented, with the presence of various key players. A large number of manufacturers hold a major share in their respective regions. Major players operating in the global advanced glycation end products market are:
- Allergan Plc
- Estée Lauder Companies
- Shiseido Company
- Beiersdorf AG
- L'Oréal S.A
- NuFACE
- Ostium Cosmetics
- PhotoMedex, Inc.
- Alma Laser
- Rodan & Fields, LLC
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