Single-use Bioprocessing Market Size to Garner Around US$ 34 Bn by 2030

According to Precedence Research, the global Single-use Bioprocessing Market size is expected to garner around US$ 34 billion by 2030 from valued at US$ 13 billion in 2020 and growing at a CAGR of 13.3% from 2021 to 2030.

Single-use technology (SUT) has become a leading technology in pre-commercial manufacturing, including preclinical and clinical scales. Over the past years, there has been a rapid growth in the adoption of SUT-based process lines, to an extent that SUT has dominated the upstream pre-commercial biopharmaceutical manufacturing. Most of the bioprocessing facilities employ a significant amount of various disposable products, contributing to revenue growth for the market for single-use bioprocessing.

Owing to the high demand for biopharmaceuticals, suppliers’ product portfolios of disposables have become more robust. Single-use bioprocessing equipment suppliers are working closely with customers to fulfill the growing expectations of customers.

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Increasing demand for disposables consumables has led to several acquisitions, mergers, and partnerships. For instance, Wego Pharmaceuticals is engaged in a partnership with GE Healthcare for the manufacturing of disposables.

Scope of the Single-use Bioprocessing market

Product Insights

The highest penetration of tubing, filters, connectors, and transfer systems in terms of usage and product availability has attributed to the largest revenue share of simple and peripheral elements in 2019. Moreover, the availability of a wide range of bags that are equipped with ports, connectors, and automation is used for multiple applications, such as storage of cell cultures, buffers, sterile media, sera, and reagents. This, in turn, is driving segment revenue in the market for single-use bioprocessing.

Furthermore, the demand for disposable probes and sensors continues to grow within the biopharmaceutical industry. The growing interest in disposables probes and sensors is displayed by both in-house manufacturers and CMOs. However, the availability of sensors is limited to a few basic analytes. This, in turn, creates opportunities for the players in the market for single-use bioprocessing, striving to capitalize on the untapped revenue in this segment.

However, apparatus and plants are expected to grow at a significant pace owing to the continuous developments in single-use bioreactors in terms of scale, application, and capacity. For instance, in January 2019, Sartorius launched BIOSTAT RM TX single-use bioreactor for closed and automated expansion of various cellular therapies.

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Workflow Insights

The single-use bioprocessing market is expected to grow due to the introduction of a wide array of SUS to be used during various phases of biomanufacturing. Single-use bioprocessing products range from bioreactors for the fermentation process to several filtration systems for downstream processing. Implementation of SUS for cell culture, liquid handling, and storage has contributed to the large share of upstream processing.

The introduction of SUTs has not made as much of an impact in downstream processing as it has made in upstream processing. In particular, the implementation of SUTs in chromatography purification is an important bottleneck for the expansion of this market for single-use bioprocessing. The primary challenge in shifting chromatography to disposable format is the cost of affinity/Ion Exchange (IEX) resins. The end-users need to amortize for resins through clean-and-reuse programs.

These challenges need to be addressed to leverage SUTs in downstream single-use bioprocessing. The growing popularity of SUS has encouraged several suppliers to develop disposable products for downstream processing. For instance, the introduction of single-use centrifuges enables the handling of very high cell densities, thereby benefitting the downstream processing techniques.

End-use Insights

The biopharmaceutical manufacturing industry is expected to significantly benefit from the growing popularity of disposables among CMOs. Contract service providers are engaged in the expansion of single-use capacity by installing new single-use bioprocessing products at their facility, thereby aiding in revenue regeneration.

Installation of expensive stainless-steel bioprocessing equipment including bioreactors at large scale for in house biomanufacturing has attributed to the relatively lesser market share for in house bio manufacturers. However, this technology has facilitated smaller firms to have control over biomanufacturing by keeping it in-house. This is anticipated to drive the uptake of disposables within in-house bio manufacturers in the market for single-use bioprocessing.

SUS has made a significant impact in clinical research settings. Single-use blood bags, transfer sets, T-flasks, and pipettes have been effectively used for cell therapy-based clinical research. The presence of training institutes like the National Institute for Bioprocessing Research and Training (NIBRT) that offer training and research solutions for the bioprocessing industry covering the various aspects of single-use bioprocessing is expected to have a positive influence on the market.

Regional Insights

A significant share of North America in this market for single-use bioprocessing can be attributed to the presence of large-scale biopharmaceutical manufacturing facilities in U.S. The biopharmaceutical sector is considered as the most R&D intensive in this country. Taking into consideration the growing popularity of disposables, U.S.-based companies continue to launch novel SUS to effectively serve domestic as well as global end-users. Such new product launches in the region are anticipated to boost the revenue share of the market for single-use bioprocessing in North America in the coming years.

The adoption of disposables has become a trend among CMOs, and this region is recognized as a significant market base for contract service providers. This factor serves as a catalyst for continued investments by local and global companies for the implementation of disposables at CDMO’s biomanufacturing plants in the region.

For instance, in January 2019, Boehringer Ingelheim expanded its commercial biologics manufacturing site in China. The expansion covered incorporation of a bioreactor with all required infrastructure and utility to support the GMP operations of 2x 2.000 L single-use bioreactor manufacturing lines.

Key Players

GE Healthcare, Sartorius AG, Lonza, and Eppendorf AG dominate the market

Market Segmentation

Single-use Bioprocessing Product Outlook

• Simple & Peripheral Elements
  • Tubing, Filters, Connectors, & Transfer Systems
  • Bags
  • Sampling Systems
  • Probe & Sensors
    • pH Sensor
    • Oxygen Sensors
    • Pressure Sensors
    • Temperature Sensors
    • Conductivity Sensors
    • Flow Sensors
    • Other Sensors
  • Others
• Apparatus & Plants
  • Bioreactors
    • Bioreactors, By Capacity
      • Upto 1000 L
      • Above 1000 to 2000 L
      • Above 2000 L
    • Mixing, Storage, & Filling Systems
    • Filtration system
    • Chromatography Systems
    • Others
• Work Equipment
  • Cell Culture System
  • Syringes
  • Others

Single-use Bioprocessing Workflow Outlook

• Upstream
• Fermentation
• Downstream

Single-use Bioprocessing End-use Outlook

• Biopharmaceutical Manufacturer
  • CMOs & CROs
  • In-house Manufacturer
  • OEM
• Academic & Clinical Research Institutes
• Others

Single-use Bioprocessing Regional Outlook

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

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