A raging issue on the first day of XVIII International AIDS Conference was whether Isoniazid (INH) Preventive Therapy (IPT) be given to all - regardless whether people have TB or not? A full-course of IPT can prevent latent tuberculosis (TB) infection from becoming active TB disease. It is very crucial and often life-saving for people living with HIV (PLHIV) who are co-infected with tuberculosis (TB) as TB continues to be the biggest killer of PLHIV.