Using the radial approach during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is associated with a fourfold reduction in major bleeding without any delay in revascularization compared with femoral access. The results, published in the July 15, 2010, issue of the American Journal of Cardiology, are consistent with a growing body of literature supporting radial over femoral access.