Medical science is ever-evolving. From biosensors to protein chips, technology and molecular biology have come together to offer the most powerful way to study biochemical activities.
Medical science is ever-evolving. From biosensors to protein chips, technology and molecular biology have come together to offer the most powerful way to study biochemical activities. Protein chips or protein microarrays are miniaturized and parallel assay systems that consist of some amounts of purified proteins in a high-density format. Their involvement has become more popular over the last few years as they help determine a variety of analytes within a single experiment. They are prepared by immobilizing proteins onto a microscope slide using a conventional contact spotter. The most popular types of slide surfaces are epoxy-derivatized or aldehyde-derived glass surfaces. Protein chips are used for clinical diagnosis or food safety analysis. On the other hand, functional protein arrays are utilized to study a variety of protein activities such as protein-liquid, protein-protein, and protein-DNA, protein-peptide interactions to detect enzyme substrates and understand the immune response.
Protein chips market scenario:
According to Allied Market Research, the global protein chip market is expected to garner $1.36 billion by 2030, growing at a CAGR of 7.5% from 2021 to 2030. The rise in prevalence of cancer, advent in the adoption of advanced technology in diagnostics, and surge in demand for personalized diagnosis technology would boost the market growth.
Over the last two decades, protein chip technology has successfully applied for quantification, simultaneous identification, and functional analysis of proteins in basic as well as applied proteome research. These systems are proven to be effective to replace singleplex analysis systems.
Protein chips for inflammation diseases:
Inflammation is the body’s defense reaction against harmful stimuli including infectious agents and tissue injury. The relationship between infecting microorganisms and the inflammatory responses of the body is complex and intricately intertwined. Due to such nature, the use of protein chips is regarded as a viable option to study inflammatory diseases. What’s more, high-density protein arrays allow new classes of autoantibodies that may cause autoimmune diseases. Moreover, a detailed study of how inflammatory diseases affect the human body would help in developing a patient-centric treatment that could work wonders compared to the conventional course of medical treatments.
The technology has a great potential for multiplexed detection as well as proteomics studies and over the years, the application of protein chips has increased rapidly. In the future, protein chip technology would become a vital tool in sectors of high-throughput biology and diagnostics. Simultaneously, development in our ability to generate high-quality proteins and antibodies would play a key role to promote the extension of this technology to model organisms.