Plasmid DNA Manufacturing Market Size To Hold USD 2.156 Mn By 2030

The global plasmid DNA manufacturing market size accounted for USD 446.13 million in 2022 and is expected to hold USD 2.156 million by 2030 with a CAGR of 21.7%. from 2022 to 2030

Gene therapy has reformed human beings and is gaining popularity in treating diseases. Plasmid therapy is the product of gene therapy. It utilizes genetically engineered circular DNA molecules to carry therapeutic genes into human cells. It is a starting material for modern therapies. Plasmid DNA is beneficial in contemporary healthcare. It is used as an agent in gene therapy, vaccine production, and research applications. It is also used to produce both viral-vector constructs and transient proteins. The transient proteins are used in the development of monoclonal antibodies. Plasmid DNA is used to treat different diseases, such as heart defects, metabolic diseases, cancer, and neurodegenerative disorders.

Growth Factors

Plasmid DNA is very vital in the healthcare industry. It is essential for the production of vaccines and next-generation cells. It is also used in the development of gene therapies. The market players are developing new plasmid DNA vaccines. Plasmids can deliver DNA with a low risk of immunogenicity. These factors are expected to boost the overall market growth. Surging awareness about cell and gene therapy significantly contributes to market expansion. Cell and gene therapy products are widely used to treat various diseases, thus catalyzing market growth. There is increasing availability of approved gene therapy products. Plasmid DNA is used to develop gene therapies and DNA vaccines for infectious diseases, enteric pathogens, and influenza.

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Factors such as increasing demand for excellent disease treatment therapies and rising research and development activities positively influence market growth. Research organizations focus on research and development activities for advanced therapies that can treat severe diseases. Furthermore, the leading companies are entering the market with advanced technologies to meet the rising demand and strengthen their foothold. An increasing number of patients choosing gene therapy have been witnessed, thus catalyzing market growth over the forecast period. This is a significant factor driving the development of the plasmid DNA manufacturing market. Gene therapy is leading in medical science and is beneficial in treating various diseases.

Digital Health Market Report Scope

Report Highlights

• By product, the viral vector segment dominates the market with the highest revenue share. It is expected to retain its dominance throughout the forecast period. This method is widely used in cell-based gene therapies, thus fostering the segment's growth.
• By application, the gene therapy segment dominates the market with an outstanding revenue share. It is expected to retain its dominance throughout the forecast period. Gene therapy is employed chiefly in the treatment of various genetic disorders. Furthermore, rapid technological advancements for the safe treatment of different diseases catalyse the segment's growth.
• By disease, infectious disease is dominating the plasmid DNA manufacturing market. It is expected to retain its dominance throughout the forecast period. DNA plasmid is used in infectious diseases treatment boosting the segment's growth. However, the cancer segment is expected to exhibit a promising CAGR in the coming years. The increasing use of plasmid DNA for cancer treatment therapy development drives this segment's growth.

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Regional Snapshots

Based on the region, North America dominated the market growth and is expected to keep growing in the coming years. The emergence of several biopharmaceutical industry players is boosting market growth across the region. Factors such as inflating disposable income, rising investments in healthcare infrastructure, growing consumer awareness regarding gene therapies, and increasing demand for gene therapy to treat various diseases significantly contribute to the region's market growth. The heavy investment in research and development activities in plasmid DNA is boosting the growth of the market in North America.

On the other hand, the Asia Pacific region is expected to exhibit a promising CAGR in the coming years. Factors such as increasing investment by the government in healthcare infrastructure and rising investment in R&D activities in plasmid DNA significantly contribute to the region's market growth. Rapid technological advancements, such as the launch of good manufacturing practices and cell culture systems, are positively influencing the regional market growth. These factors make Asia Pacific the fastest-growing region for plasmid DNA.

Market Dynamics:

Driver: Increasing demand for plasmid DNA manufacturing for producing various vaccines

The increasing demand for plasmid DNA manufacturing for the production of vaccines is significantly contributing to market growth. It acts as the primary market driver. Plasmid DNA manufacturing is widely used for developing DNA vaccines, gene therapy, immunotherapy, and others. In line with this, the rising demand for gene therapy positively influences the market growth. Furthermore, the growing demand for immunotherapy is expected to drive market growth during the forecast period. Plasmid DNA manufacturing offers various benefits, such as effective gene delivery, improved transfection efficiency, and stable gene expression. This catalyzes market growth. Various clinical studies are conducted to examine plasmid DNA efficacy and safety. There is a growing contract manufacturing business for plasmid DNA manufacturing. Various companies are collaborating with multiple organizations to produce plasmid DNA.

Restraint: High cost of gene therapies

The high cost of gene therapies and insertional mutagenesis are expected to restrict the global plasmid DNA manufacturing market. Plasmid DNA manufacturing is a complicated process and involves very high costs. The manufacturing scale-up is hindering the growth of the global plasmid DNA manufacturing market. It acts as a barrier to its commercialization. These factors are hampering the market growth.

Opportunity: Continuous Innovations in Biopharmaceutical Industry

Innovations in Biopharmaceutical Industry offer numerous market growth opportunities in the forecast period. There has been an increasing demand for innovation in existing manufacturing technologies. This demand is seen to fulfill the requirement for appropriate products. It is expected to provide immense growth opportunities for industry players.

Challenge: Insertional mutation

Various factors are challenging the growth of the plasmid DNA manufacturing market. However, the insertional mutation is the main factor impeding market growth. This problem needs to be solved in gene therapy. Various risks are involved in inserting a gene into a tumor suppressor gene. There are also risks in activating an oncogene with vectors. To solve this challenge, vectors that can't be incorporated easily into the genome can be used.

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Key Developments in the Marketplace:

• In January 2020, a new contract manufacturing unit was developed by Helixmith&Genopis.
• In December 2020, Thermo Fisher Scientific planned to set up a new GMP plasmid DNA manufacturing unit in California.

Some of the Prominent Players

OriGene Technologies,Inc, Integrated DNA Technologies, Inc, Thermo Fisher Scientific, Inc, ProMab Biotechnologies, Inc, Eurofins Scientific, Biomatik, ProteoGenix, Bosyer Biological Technology, GenScript, Brooks Automation, Inc (GENEWIZ), Twist Bioscience, Codex DNA and Others.

Segments Covered in the Report

By Method

• Solid-phase synthesis
• Chip-based synthesis
• PCR- based Enzyme synthesis

By Service

• Antibody DNA synthesis
• Viral DNA synthesis
• Others

By Application

• Gene & cell therapy development
• Vaccine development
• Diseases diagnosis
• Others

By End Users

• Biotechnology & pharmaceutical companies
• Academic & government research institutes
• Contract research organizations

Regional Segmentation

• North America (U.S., Canada, Mexico)
• Europe (Germany, France, U.K., Italy, Spain, Rest of Europe)
• Asia-Pacific (China, Japan, India, Southeast Asia and Rest of APAC)
• Latin America (Brazil and Rest of Latin America)
• Middle East and Africa (GCC, North Africa, South Africa, Rest of MEA)

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Thanks for reading you can also get individual chapter-wise sections or region-wise report versions such as North America, Europe, or the Asia Pacific.

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