CAMBRIDGE, Mass.--(BUSINESS WIRE)--ARIAD Pharmaceuticals, Inc. (NASDAQ: ARIA) today announced publication, for the first time, of the high-resolution structure of the protein responsible for one of the major clinically relevant genetic variants of drug-resistant chronic myeloid leukemia (CML). These findings by a team of ARIAD scientists were used to guide the design of ARIAD’s oral multi-targeted kinase inhibitor, AP24534, for use in CML and other cancers. The findings were published in the September issue of Chemical Biology and Drug Design. ARIAD plans to file an investigational new drug application for AP24534 by the end of this year to begin clinical trials.
