Omega Therapeutics

20 Acorn Park Drive
STE 400
United States

Tel: (617) 949-4359


NextGen Class of 2021
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About Omega Therapeutics

About Omega Epigenomic Controllers™ and Omega Epigenomic Programming™ 
Omega Therapeutics is developing a new class of engineered and modular therapeutics, called Omega Epigenomic Controllers™, that can be programmed to precisely downregulate or upregulate the level of expression of any of the 25,000+ human genes, individually or collectively, with controlled durability, to treat and potentially cure disease. Omega Epigenomic Programming™ represents an entirely new and 3 breakthrough approach, allowing the Company’s product candidates to drug previously undruggable targets across a broad range of diseases. The foundation of Omega’s platform lies within the three-dimensional architecture of the human genome and its accompanying regulators, which are organized into distinct and conserved structures called Insulated Genomic Domains (IGDs). Omega’s technology exploits the topology and functionality of these IGDs as druggable targets to activate the genome’s innate ability to treat and cure disease. Omega’s medicines are being developed to be dosed only as frequently as therapeutically necessary by intervening at the pre-transcriptional level and function without altering the native human genetic code or nucleic acid sequences. 
About Omega Therapeutics 
Omega Therapeutics is a privately held, development-stage biotechnology company pioneering the field of epigenomic programming to precisely regulate and control the human genome to treat and cure disease. Omega’s breakthrough science has enabled it to tap into nature’s universal operating system, that epigenetically controls the human genome, to target the most fundamental genomic processes which fuel cellular growth, differentiation, and gene expression. Omega Therapeutics was founded by Flagship Pioneering in 2017 and currently has eight programs in various stages of preclinical development. The Company is strategically pursuing specific disease targets that have not been successfully addressed through conventional modalities, including certain oncology indications, liver disease, serious inflammatory conditions, and acute respiratory distress syndrome (ARDS) among others. Omega’s mission is to transform medicine and deliver the therapies of tomorrow. 


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