Three non-animal assays formally validated and regulatory adopted including DPRA, the KeratinoSens assay and the human cell line activation test are introduced to assist non-animal skin sensitization testing.
Creative BioMart, today announced the release of Non-Animal Skin Sensitization Testing Services, a novel one for protein analytical service. Three non-animal assays formally validated and regulatory adopted including direct peptide reactivity assay (DPRA), the KeratinoSens™ assay and the human cell line activation test (h-CLAT) are introduced to assist non-animal skin sensitization testing.
The Direct Peptide Reactivity Assay (DPRA) is an in chemico method used to predict epidermal protein binding. It uses HPLC to measure the depletion of synthetic peptides incubating with test articles. The KeratinoSens™ Assay is an in vitro keratinocyte activation test. It uses luminescence detection to measure luciferase signal reflecting the activation by the sensitizers of endogenous Nrf2 dependent genes. The Human Cell Line Activation Test (h-CLAT) is an in vitro dendritic cell activation test. It uses flow cytometry to measure CD86 and CD54 expression on treated THP-1 cells in culture.
“Allergic Contact Dermatitis (ACD) is a complex disease, and it is estimated that 15-20% of the general population suffers from contact allergy, with increasing prevalence. Assessment of skin sensitization potential is therefore an important component of the safety evaluation process for cosmetics and personal care products, pharmaceuticals and agrochemical products. We are quite pleased to be able to offer this new service, providing our customers integrated testing strategy within their existing testing program.” said Linna, the chief marketing staff in Creative BioMart.
To know more information about Non-Animal Skin Sensitization Testing Services in Creative BioMart, please visit https://www.creativebiomart.net/Non-Animal-Skin-Sensitization-Testing-Services.htm.
About Creative BioMart
Starting from a small supplier of proteins and enzymes for academic institutes and biotech companies, Creative BioMart has always been focusing on developing high quality protein products including recombinant protein, GMP protein, native proteins, tissue lysate, etc. and efficient protein manufacturing techniques. Over the past decade, our products and services are proved to have served our customers well and our brand has become one of the most trustworthy in the market.
