Shire Acquisition Inc. (Corporation) (TSX: SHQ), a subsidiary of Shire Pharmaceuticals Group plc (Shire) (LSE: SHP; NASDAQ: SHPGY) that was set up to hold the shares of BioChem Pharma Inc. (BioChem) after the Shire and BioChem merger, announced today that Mr. Richard de Souza has resigned as director of the Corporation effective as of February 9, 2004.