LOS ANGELES & CAMBRIDGE, Mass.--(BUSINESS WIRE)--AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused on the discovery and development of novel, targeted cancer medicines, today announced encouraging preclinical data of AV-412, a novel, next generation oral tyrosine kinase inhibitor of EGFR/HER2 using AVEO’s unique EGFR mutant and drug-resistant lung cancer tumor models. The results from the preclinical study showed that AV-412 is greater than 10 times more potent than erlotinib in genetically engineered lung tumor models with the EGFR L858R mutation, producing rapid and complete tumor regression at a daily dose of 1 mg/kg. Additionally, AV-412 is also active against tumors carrying the EGFR kinase-resistance mutation EGFR L858R/T790M. These data were presented today in the EGFR Inhibition poster session at the 100th American Association for Cancer Research (AACR) Annual Meeting.
