Whole Exome Sequencing Market Size to Reach USD 4.2 billion by 2025 | Emergen Research

The global whole exome sequencing market size is expected to reach USD 4.2 billion by 2025 from USD 1.5 billion in 2020, at a CAGR of 25.1%. The growth of this market is majorly driven by the rising incidences of genetic disorders and cancer, technological advancements in sequencing platforms, and increasing government initiatives and funding for genomics research.

Advances in DNA sequencing have transformed genomics research, providing insights into the function of genes and enabling the discovery of new disease-related variants. In particular, next-generation sequencing (NGS) has emerged as a powerful tool for analyzing genomes at unprecedented speed and scale.

One type of NGS technology is whole exome sequencing (WES), which allows for the rapid and cost-effective sequencing of the protein-coding regions of the genome. WES has been used to identify novel genetic variants associated with disease, to improve our understanding of disease mechanisms, and to guide clinical decision-making.

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Whole Exome Sequencing (WES) is next-generation technology used to determine the complete set of genes that are expressed in an individual. WES can help in identifying genetic variations associated with Mendelian disorders and complex diseases, thereby providing insights for therapeutic intervention.

The rapidly decreasing costs of sequencing and the availability of new sequencing technologies are key drivers of growth in the whole exome sequencing market. In addition, the increasing application of whole exome sequencing in rare disease diagnosis and cancer genomics is expected to boost market growth during the forecast period. However, the lack of skilled personnel and the high costs associated with data analysis are restraining factors for the growth of this market.

Some Key Highlights in the Report:

  • Key companies in the market include Illumina, Inc., Thermo Fisher Scientific, Inc., Agilent Technologies, Hoffman-La Roche AG, Eurofins Scientific Group, GENEWIZ, Inc., Knome, Inc., Macrogen, Inc., Ambry Genetics Corp., and Beijing Genomics Institute.
  • In January 2019, The U.S. Food and Drug Administration (FDA) approved Foundation Medicine's FoundationOne CDx as the first next-generation sequencing-based in vitro diagnostic for any solid tumor that can be ordered by any licensed U.S. healthcare provider.
  • In February 2019, Thermo Fisher Scientific Inc., launched Ion Torrent Genexus System, which is the first next-generation sequencing system that can be used for whole-genome sequencing.

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  • The services segment accounted for the largest share of the global WES products and services market in 2020 due to the increasing adoption of NGS-based diagnostics, the need for comprehensive genomic analysis, and the availability of skilled personnel. Services are further segmented into library construction, target enrichment, sequencing, and data analysis.
  • The diagnostics segment accounted for the largest share in 2020 due to the increase in the number of diagnostic centers and the growing adoption of WES for cancer diagnosis. However, the therapeutics segment is expected to grow at the highest CAGR during the forecast period due to ongoing clinical trials and government initiatives to promote WES-based drug development.
  • Sequencing by synthesis segment is expected to register robust revenue CAGR during the forecast period owing to the launch of new technology and reagents in this field and the higher accuracy and flexibility of this technology.
  • Hospitals and reference laboratories segment is expected to dominate the market over the forecast period due to the increase in the number of hospitals and reference laboratories that are offering genomic sequencing services. Also, government initiatives to promote genomic research is projected to boost the market growth over the forecast period. For instance, in February 2019, The U.S. National Institutes of Health's All of Us Research Program announced that it would sequence the genomes of one million or more participants.
  • Personalized medicine segment is expected to register significant revenue share over the forecast period due to the increasing demand for patient-specific diagnosis and treatment. Also, the development of new targeted therapeutics and genomic sequencing technologies is projected to fuel the market growth over the forecast period.
  • North America is expected to dominate the market over the forecast period due to the increase in research and development activities in genomics and increase in government initiatives to promote genomic research. For instance, in September 2018, the U.S. National Institutes of Health announced that it would provide USD 25 million for the All of Us Research Program to support whole-genome sequencing of volunteers in the program.

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For the purpose of this report, Emergen Research has segmented the global whole exome sequencing market on the basis of product, application, technology, end-use, and region:

Product Outlook (Revenue, USD Million; 2018-2028)

  • Products
  • Kits
    • DNA Fragmentation End Repair, A-Tailing and Size Selection
    • Library Preparation Kits
    • Target Enrichment Kits
  • Services
    • Sequencing Services
    • Data Analysis Services

Application Outlook (Revenue, USD Million; 2018-2028)

  • Diagnostics
  • Cancer
  • Monogenic Disorders
  • Diabetes
  • Others
  • Drug Discovery and Development
  • Personalized Medicine
  • Agriculture and Animal Research
  • Others

Technology Outlook (Revenue, USD Million; 2018-2028)

  • Sequencing by Synthesis
  • Ion Semiconductor Sequencing
  • Others

End-Use Outlook (Revenue, USD Million; 2018-2028)

  • Academic Institutions & Research Centers
  • Hospitals & Clinics
  • Pharmaceutical & Biotechnology Companies
  • Others

Regional Outlook (Revenue, USD Million; 2018-2028)

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • U.K.
    • Germany
    • Italy
    • France
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • South Korea
    • Rest of APAC
  • Latin America
    • Brazil
    • Rest of LATAM
  • Middle East & Africa
    • Saudi Arabia
    • U.A.E.
    • South Africa
    • Rest of MEA


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