MedPageToday -- Warming a local anesthetic to body temperature before injection can help ease the pain associated with infiltration of the drug, a meta-analysis found. In 18 studies that included 831 patients, the mean difference in pain scores with local injection of a warmed anesthetic was -11 mm (95% CI -14 to -7) on a 100-point scale, according to Anna Taddio, PhD, of the University of Toronto, and colleagues.
