Advances in recombinant technology have enabled researchers to utilize the thrombolytic activity of tissue plasminogen activator in synthetic products.
Advances in recombinant technology have enabled researchers to utilize the thrombolytic activity of tissue plasminogen activator (tPA) in synthetic products. The tissue plasminogen activator market has thus witnessed a growing array of recombinant tissue plasminogen activators with useful pharmacokinetic and pharmacodynamic properties. Key products comprise alteplase, reteplase, and tenecteplase. Numerous regulatory agencies, particularly, the U.S. FDA has highlighted the therapeutic potential of these in a range of diseases, notably including ischemic stroke, myocardial infarction, and thrombolysis. Relentless focus on improving the half-life of some of these recombinant tPAs is propelling advances in the tPA market over the past few years.
Tissue plasminogen activators are usually administered through regional intra-arterial routes or intravenously. Recent body of clinical studies have shown that tPAs can be a risk marker for cardiovascular disease. Growing in vivo studies on fibrinolytic system is also boosting the market. tPA products have in recent years grown in popularity for the treatment of acute ischemic stroke (AIS). Several studies on reversing tPA toxicity are expected to boost the tissue plasminogen activator market.
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Global Tissue Plasminogen Activator Market: Growth Dynamics
A substantial proportion of the worldwide populations suffer from stroke at some point in their lives. The numbers of people who die due to strokes are also bewildering, especially in developed countries such as the U.S. In addition, the growing prevalence of cardiovascular diseases around the world has been putting large pressure on the quality of patient care. All these factors have catalyzed the demands in the tPA market. However, several contraindications need to be taken in consideration while using tPA in therapies. Adverse reactions commonly include cardiogenic shock, hypotension, muscle pain, allergic reaction, and intracranial hemorrhage.
Nevertheless, the vast clinical prospect of recombinant tPAs has put pressure on healthcare teams world over to circumvent these concerns. To this end, the healthcare team comprising nurses, pharmacists, and physicians along with the research fraternity, have been making concerted efforts. Meanwhile, continuous and rapid advances in discovering novel thrombolytic therapies are expected to impart momentum to the future stride in the market. The utilization of tPA in early reperfusion therapy as a life-saving therapy will likely expand the potential of the tissue plasminogen activator market.
Global Tissue Plasminogen Activator Market: Notable Developments
Over the past few years, the health care industry has witnessed rapid advances in evaluating various treatment modalities for ischemic strokes and consequently increasing the survival rates in patients. This has opened new windows of opportunities in the tissue plasminogen activator market. Several of these advances have been fueled by growing expertise and knowledge of emergency medical services (EMS) providers. Numerous comprehensive stroke centers are expected to benefit from such knowledge. A recent study by a team of researchers at the U.S. aimed to assess the preparedness of EMS in managing stroke patients in prehospital care settings. Such focus will help expand the clinical prospects of the application of tPA, opening new avenues in the tissue plasminogen activator market.
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Some of the key biotech companies aiming for higher stakes in the tissue plasminogen activator market are
- Bayer AG
- Merck & Company
- Cadila Healthcare Ltd.
- Sigma-Aldrich
- Genentech
- Roche
Global Tissue Plasminogen Activator Market: Regional Assessment
On the regional front, North America has been showing considerable prospects in the tissue plasminogen activator market. A large degree of the growth is propelled by recent advances in health care industry toward the management of patients with strokes and numerous cardiovascular diseases. Extensive research over the recent years in improving the biological activity and efficacy of tPA has also expanded the potential of the regional market.
Meanwhile, among other key markets, Asia Pacific is worth mentioning. Their contribution to the global market is likely to grow substantially in the not-so-distant future.
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