The respective size of two major arteries, visible on a simple computed tomography, or CT, scan, is a strong predictor of the risk of exacerbation of chronic obstructive pulmonary disease, according to new research from the University of Alabama at Birmingham published online Sept. 3, 2012, in the New England Journal of Medicine. The research team says that an increase in the size of the pulmonary artery relative to the size of the aorta is a valid indicator that a patient with COPD is at risk for exacerbating their disease.