According to Nova one advisor, the global Oligonucleotide Synthesis market size is expected to hit around USD 4.9 billion by 2030 from valued at USD 2.1 billion in 2021 and growing at a CAGR of 14.2% from 2022 to 2030.
According to Nova one advisor, the global Oligonucleotide Synthesis market size is expected to hit around USD 4.9 billion by 2030 from valued at USD 2.1 billion in 2021 and growing at a CAGR of 14.2% from 2022 to 2030. Increasing use of synthesized oligonucleotides in diagnostics and research applications, and Technological advancements in synthetic chemistry are projected to drive the global oligonucleotide synthesis market during the forecast period
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Report Scope of the Oligonucleotide Synthesis Market
| Report Coverage | Details |
| Market Size | USD 4.9 Billion by 2030 |
| Growth Rate | CAGR of 14.2% from 2022 to 2030 |
| Largest Market | North America |
| Fastest Growing Market | Asia Pacific |
| Base Year | 2021 |
| Forecast Period | 2022 to 2030 |
| Segments Covered | Product Product Type, Applications, End User and Region, |
| Companies Mentioned |
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Technological advancements in synthetic chemistry to Drive Global Oligonucleotide Synthesis: Key Drivers
- The advances in the technological development of organic molecules are expected to drive the growth of the oligonucleotide synthesis market
- The advanced synthesis of oligonucleotides provides longer oligos with better sequence fidelity and higher purity that can be used in a number of molecular biology applications
- Various pharmaceutical and biotechnology companies are continuously working on developing newer and advanced methods in synthetic chemistry
- For instance, Integrated DNA Technologies, leader of synthesized oligonucleotides has developed various pioneered methods to synthesize oligonucleotides of extreme lengths. The company has developed oligonucleotides up to 200 base length which is used with mass spectrometry for the manufacture of mini-genes.
Increasing use of Synthesized Oligonucleotides in Diagnostics and Research Applications Boost Market Growth
- Oligonucleotides have a wide range of applications in areas such as molecular biology, biotechnology, and diagnosis
- Natural oligonucleotides have been extensively used for the selection and determination of DNA sequences (hybridization probes or affinity purification), gene construction, and site-directed mutagenesis
- They constitute the basic reagents for PCR technologies. They are also used to selectively inhibit gene expression in in vitro studies for diagnostic purpose and more recently, their ability to interact with proteins has generated immense opportunity for therapeutic use.
- Along with diagnostics, they are widely used in research studies. Combinatorial technology is another research area where oligonucleotides and their analogs are extensively employed.
Limitations in the Synthesis of Oligonucleotides to Hamper Market
- An oligonucleotide is a single-stranded chain consisting of a number of nucleoside units linked together by phosphodiester bridges
- Mostly in oligonucleotide synthesis, phosphodiesters are formed between a 3’-hydroxyl group bearing a phosphate derivative and a 5’-hydroxyl group of another nucleoside
- The occurrence of side reactions sets practical limits for the length of synthetic DNA oligonucleotides (up to about 200 nucleotide residues) because the number of errors accumulates with the length of the oligonucleotide being synthesized
- To synthesize RNA with longer nucleotides base, that is more than 50 nucleotides is very complex and difficult to prepare
- But, most biologically important RNA molecules such as ribozymes, aptamers, and riboswitches are significantly longer than 50 nucleotides, so new approaches for the synthesis of RNA analogs are urgently required
Some of the prominent players in the Oligonucleotide Synthesis Market include:
- GE Healthcare
- Thermo Fischer Scientific
- Agilent Technologies, Inc.
- Merck KGaA
- Integrated DNA Technologies, Inc.
- Kaneka Eurogentec S.A
- BioAutomation
- Gene Design, Inc.
- Eurofins Genomics
- ATDBio, Ltd..
Segments Covered in the Report
This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2017 to 2030. For this study, Nova one advisor, Inc. has segmented the global Oligonucleotide Synthesis market
Product Product Type
- Reagents & Consumables
- Equipment
- Synthesized Oligonucleotides
- DNA
- RNA
- Others
Applications
- Research
- Polymerase Chain Reaction
- Next Generation Sequencing
- Others
- Therapeutics
- Antisense Oligonucleotides
- Nucleic Acid Aptamers
- Diagnostic
End User
- Biotech & Pharma Companies
- Research Inst.
- Diagnostic Labs
By Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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