Johns Hopkins scientists have successfully used new techniques to search the yeast genome for genes that help keep copied chromosomes together, protecting the integrity of the organism’s genetic material during cell division.By combining two genome-wide screens, the researchers were able to narrow down the dozens of genes identified by the first screen to just 17 that made both cut-offs -- a number small enough to be cost- and time-efficient to consider in some detail. Their report appears in the April issue of Molecular Biology of the Cell.
