TORONTO--(BUSINESS WIRE)--The first U.S. patient to enroll in Functional Neuromodulation’s ADvance Study was successfully implanted with a deep brain stimulation (DBS) system. ADvance will evaluate the safety and potential clinical benefit of DBS of the fornix (DBS-f), a major inflow and output pathway in the brain’s memory circuit, for patients with mild Alzheimer’s. The ADvance Study is making rapid progress, with six implants conducted to date. The first U.S. implant was done at Johns Hopkins and five patients have been implanted at Toronto Western Hospital. The University of Pennsylvania has joined the study, bringing the total to five leading North American research centers participating in ADvance.