The global cell and tissue preservation market was evaluated at USD 4.22 billion in 2023 and is expected to attain valuation around USD 11.98 billion by 2033, growing at a CAGR of 11.01% from 2024 to 2033. The growth of the cell and tissue preservation market is propelled by several factors. Long-term storage of cells or tissues at low temperatures can lead to alterations in their functioning, underscoring the importance of effective preservation techniques.
Key Insights
- North America has accounted 40.14% revenue share in 2023.
- U.S. cell and tissue preservation market size was valued at USD 1.19 billion in 2023 and is expected to hit around USD 3.55 billion by 2033.
- U.S. cell and tissue preservation market is growing at a CAGR of 11.59% from 2024 to 2033.
- By region, Asia Pacific is expected to grow at the fastest rate during the forecast period.
- By type, the cell segment has accounted 53% revenue share in 2023.
- By type, the tissue segment is expected to grow at the fastest rate during the forecast period.
- By application, the therapeutics segment has accounted revenue share of 40% in 2023.
- By application, the IVF treatment segment is expected to grow at the fastest rate during the forecast period.
- By product, the equipment segment dominated the market in 2023.
- By end-user, the biobanks segment dominated the market with revenue share of 68% in 2023.
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Market Overview
The cell and tissue preservation market is experiencing rapid growth driven by preservation of cells is fundamental in cell culture, with freezing being the most effective method for animal cells using liquid nitrogen or cryogenic freezers. This biologically inert state allows cells to be preserved for extended periods, addressing the growing need for human tissues and organs for transplantation. Preservation processes typically involve specialized solutions containing isotonic saline-based solutions, cryoprotective agents (CPAs) like DMSO or glycerol, and sometimes proteins such as fetal bovine serum or human albumin.
Determining the optimal composition for different cell types is crucial for successful preservation. In advancements, existing preservation methods like slow freezing, vitrification, dry state preservation, and hypothermic/normothermic storage still have limitations that hinder their widespread clinical deployment. Addressing these challenges and developing efficient preservation methodologies is vital for unlocking the full potential of biomedical applications in the cell and tissue preservation market.
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Regional Stance
North America emerged as the dominant force in the cell and tissue preservation market, driven by the robust healthcare ecosystem of the United States. The American healthcare system's substantial investments in medical research and pharmaceutical development have yielded groundbreaking discoveries and enhanced treatments across various domains. With the United States leading the world in new drug and medical devices approvals and boasting the highest number of Nobel laureates in chemistry and medicine, the region sets a benchmark for innovation and scientific excellence. The advanced degree of medical specialization in the U.S. further solidifies its position as a global leader in healthcare. These factors collectively contribute to North America's prominence in the cell and tissue preservation market, reflecting its unparalleled commitment to advancing medical science and improving patient care.
During the forecast period, Asia Pacific is poised to be the most opportunistic market for cell and tissue preservation, driven by the region's rapid growth in the healthcare industry. Countries like Singapore, Malaysia, South Korea, and Taiwan have become prominent medical tourism hubs, attracting patients worldwide with their medically advanced institutions.
The growth of Asia's healthcare industry is propelled by the emergence of healthtech, utilizing technologies such as medical wearables, centralized databases, AI, and mobile advancements to revolutionize medical practices. Additionally, the region's remarkable economic transformation contributes to the expansion of healthcare opportunities. With Asia Pacific undergoing significant advancements and economic growth, it presents substantial prospects for the cell and tissue preservation market, solidifying its position as a pivotal player in the global healthcare arena.
Report Highlights
By Type
The tissue segment emerged as the frontrunner in the global cell and tissue preservation market, with advancements in tissue preservation significantly enhancing patient outcomes, particularly in liver transplantation cases. Although tissue preservation has improved patient survival rates, the demand for liver transplantation continues to outweigh the availability of organs. Moreover, the use of human allogeneic tissues, including skin, heart valves, and blood vessels, has become standard practice in medicine, further driving the demand for tissue preservation.
However, the limited supply of these valuable resources poses a challenge to meeting clinical demands. Consequently, the development of living engineered constructs has emerged as a crucial area in biomedical science, alongside bio-preservation techniques for both donor tissues and manufactured products, indicating promising growth opportunities in the tissue segment of the cell and tissue preservation market.
The cell segment is anticipated to experience the fastest growth during the forecast period within the global market. Cell cryopreservation, a pivotal process in this segment, involves maintaining cellular life at extremely low temperatures. This preservation technique employs cryoprotective agents (CPAs) to safeguard cellular structures from damage during cooling and rewarming processes. As advancements in cell cryopreservation techniques continue to evolve, driven by the increasing demand for cell-based therapies and regenerative medicine, the cell segment is poised for substantial expansion, presenting significant growth opportunities in the cell and tissue preservation market.
By Application
The therapeutics segment asserted dominance in the global market based on application, with cryopreservation emerging as a widely adopted strategy in cell manufacturing facilities. Therapeutic cells are cryobanked in liquid nitrogen tanks until required for patient infusion, highlighting the critical role of cryopreservation in therapeutic applications. Cryoprotective agents play a pivotal role in preserving various cell types, such as sperm cells, oocytes, hepatocytes, and embryos. In fundamental research and therapeutic applications, cryopreserved cells and tissues hold immense significance. Achieving long-term storage and preservation without loss of cellular viability would significantly enhance their therapeutic utility, further underscoring the importance of cryopreservation techniques in advancing therapeutic outcomes and driving growth in the therapeutics segment of the cell and tissue preservation market.
The IVF treatment segment is poised to exhibit the highest compound annual growth rate (CAGR) during the forecast period in the global market. Fertility preservation, a key aspect of this segment, safeguards reproductive tissues to enable individuals to conceive in the future. This treatment option is sought by individuals facing challenges such as cancer, age-related fertility decline, transgender care, or other health conditions. Fertility preservation has enabled many individuals to successfully conceive healthy babies after undergoing treatment. The process involves preserving gametes, embryos, gonadal tissues, or cells for those at risk of infertility due to various factors. Adult patients have the opportunity to preserve eggs, sperm, or embryos for future use with assisted reproductive technologies, allowing them to have biologically related offspring. With the increasing demand for fertility preservation options, driven by growing awareness and advancements in assisted reproductive technologies, the IVF treatment segment is poised for significant growth, presenting lucrative opportunities in the market.
By Product
In the global cell and tissue preservation market, the equipment segment emerged as the dominant in 2023. Cryopreservation, a pivotal process within this segment, involves the use of low temperatures to preserve cells and tissues for future utilization. This technique provides a continuous supply of tissues and genetically stable living cells, serving various purposes in research and biomedical processes. End users seeking the best cryopreservation equipment for laboratory use must conduct thorough research considering factors such as cell type, budget constraints, and required features. By staying abreast of modern equipment and recent advancements, end users can ensure optimal preservation outcomes, highlighting the significance of equipment selection in driving efficiency and efficacy in cell and tissue preservation.
During the forecast period, the software segment is poised to be the most opportunistic in the global cell and tissue preservation market. Within this segment, active Controlled Rate Cooling (CRC) devices play a crucial role in monitoring and controlling the cooling process of representative sample vials, straws, or bags. These devices follow pre-established programs to achieve specific cooling profiles, ensuring optimal preservation conditions for cells and tissues. As the demand for precise temperature control and automation increases in cell and tissue preservation processes, software solutions become essential for enhancing efficiency and maintaining quality standards. Leveraging advanced software technology allows for improved monitoring, control, and documentation of preservation procedures, driving growth and innovation in the software segment of the cell and tissue preservation market.
By End User
The biobanks segment emerged as both the dominant and fastest-growing end user in the global cell and tissue preservation market. Cryopreservation, often referred to as biobanking, involves the cryogenic preservation of DNA, blood, tissues, and reproductive cells, offering a viable conservation option for a diverse range of taxa groups. With the increasing utilization of cryopreserved cells, the demands placed on the biobanking industry are escalating and evolving rapidly. Merely providing samples with high immediate post-thaw viability is no longer sufficient. Biobanks must adapt to meet the evolving needs and expectations of researchers and stakeholders, emphasizing the importance of innovation and efficiency in preserving valuable biological resources. As the biobanking industry continues to grow and evolve, it plays a pivotal role in driving advancements in cell and tissue preservation technologies and practices.
Market Dynamics
Driver
Ultra-low temperature storage techniques
Tissue and organ transplantation remains a vital lifesaving measure for critically ill patients. Current organ preservation methods typically offer only short-term storage, failing to meet the growing demand for organ transplants. With conservative estimates suggesting that less than 10% of the global demand for organ transplants is met, there is a pressing need for more effective preservation solutions. Ultra-low temperature storage techniques have emerged as a promising solution, capable of achieving long-term, high-quality preservation of tissues and organs. This advancement has garnered significant attention within the medical community, driving growth in the cell and tissue preservation market as healthcare providers seek innovative solutions to meet the rising demand for organ transplantation and improve patient outcomes.
Restraint
Lack of species-specific protocols
A significant obstacle hindering the growth of the cell and tissue preservation market is the absence of species-specific protocols to meet the diverse cryobiological requirements of cells and tissues. The challenge lies in understanding and overcoming species-specificities, particularly concerning the viability of frozen gametes and reproductive tissues. Most cryopreservation protocols have been optimized for domestic species or humans, overlooking the substantial diversity in cryobiological properties among different cell types and tissues. This limitation poses a significant barrier to the cryopreservation of wild species germplasm, thereby restricting the market's growth potential. Addressing this restraint requires concerted efforts to develop tailored cryopreservation protocols for diverse species, facilitating broader adoption of cell and tissue preservation techniques across various domains.
Opportunity
Increasing demand for Assisted Reproductive Technologies (ART)
The rising demand for Assisted Reproductive Technologies (ART) coupled with advancements in cryopreservation techniques is reshaping the therapeutic landscape in fertility treatment, presenting significant opportunities in the cell and tissue preservation market. As societal changes and advancements in medical science drive the expansion of indications for ART, there is a growing desire and opportunity to preserve fertility for various reasons. This includes "social" reasons among women seeking to enhance their chances of conception at an older age, as well as medical reasons such as preserving oocytes before undergoing cytotoxic anticancer therapy. Cryopreservation in ART has already revolutionized the therapeutic landscape, offering new avenues for fertility preservation. Moreover, ongoing advancements in cryopreservation protocols and their applications to specific patient groups further enhance the potential of cell and tissue preservation techniques, opening doors for innovation and growth in the market. As the demand for fertility preservation continues to rise, fueled by evolving societal and medical trends, the cell and tissue preservation market is poised for significant expansion and opportunity.
Recent Developments
- In May 2024, Upkara announced the launch of a proprietary technology that eliminates the need for cold storage or lyophilization for preserving biological molecules, thereby simplifying manufacturing, shipping, and usage of analytical products like research assays and diagnostic test kits.
- In February 2022, OriGen received a CE Mark and globally launched the CryoStore FLEX Freezing Bag.
Key Players in the Cell and Tissue Preservation Market
- Thermo Fisher Scientific, Inc.
- MerckKGaA
- BD
- Agilent Technologies, Inc.
- Cytiva
- Lonza
- Avantor, Inc.
- BioLifeSolutions Inc.
- FUJIFILM Irvine Scientific
- AMSBIO
- STEMCELL Technologies Inc.
- Princeton CryoTech
- LGC SeraCare
- CellGenix GmbH
- Corning Incorporated
Market Segmentation
By Type
- Cell
- Mammalian Cells
- Others (Microorganisms and Plant Cells)
- Tissue
- Blood
- Bone
- Soft Tissues
- Skin
- Others
By Application
- Therapeutics
- Drug Discovery
- Gene therapy
- IVF treatment
- Cell therapy
- Research & Development
By Product
- Equipment
- Freezers
- Refrigerators
- Storage Systems
- Others
- Software
- Bio-preservation Media
- Home-brew Media
- Pre-formulated Media
By End User
- Biobanks
- Hospitals
By Cell Provider
- CD34+
- CD19+
- MSC
- iPSC
- hESC
- Tumor Cells
- Others
By Geography
- North America
- Europe
- Asia-Pacific
- Latin America
- Middle East & Africa (MEA)
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