The global Real Time Polymerase Chain Reaction (qPCR) market size was USD 4.64 Billion in 2021 and is expected to register a revenue CAGR of 7.8% during the forecast period.
The global Real Time Polymerase Chain Reaction (qPCR) market size was USD 4.64 Billion in 2021 and is expected to register a revenue CAGR of 7.8% during the forecast period.
Increasing incidence of chronic disorders, such as Human Immunodeficiency Virus (HIV), malaria, hepatitis, and cancer and significant technological advancements in qPCR devices that provide high performance and are more efficient, are major factors driving market revenue growth. According to World Health Organization (WHO), nearly 10 million deaths were accounted for in 2020. About 30% of cancer cases in low- and lower-middle-income countries are caused by cancer-causing diseases such as Human Papillomavirus (HPV) and hepatitis. Cancer is among the leading cause of death worldwide, while breast cancer is the most prevalent type of cancer with 290,560 new cases anticipated in the U.S. in 2022.
Real time Polymerase Chain Reaction (qPCR) a technique used to monitor the progress of a PCR reaction in real-time. It is also known as a quantitative polymerase chain reaction (qPCR), which is a laboratory technique of molecular biology based on Polymerase Chain Reaction (PCR). Recent technological advancements in Real Time Polymerase Chain Reaction (qPCR) devices are also driving market revenue growth. For instance, on 9 February 2022, New England Biolabs (NEB), a U.S.-based production and discovery of enzymes for molecular biology applications announced to release its first lyophilized product manufactured by Fluorogenics which is LyoPrime Luna Probe One-Step RT-qPCR Mix with Uracil-DNA Dlycosylase (UDG). This lyophilized master mix allows for sensitive, linear real-time detection of target Ribonucleic Acid (RNA) sequences in a format that is stable at room temperature while displaying same robust characteristics and performance as previously published liquid 4X mix.
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Driver: Increasing food safety standards and rising focus on food security
Detection of bacterial contaminations is an essential part of food safety testing that lowers risk of causing consumer intoxication. There is an increased concern for food safety, and rigorous microbiological quality control methods, which are required throughout the food chain. World Health Organization (WHO) estimates that each year, food contaminated with bacteria, viruses, parasites, poisons, or chemicals leads to over 600 million illnesses and 420,000 deaths globally. In addition, unsafe food has an annual productivity cost to low- and middle-income countries of about USD 95 billion, hence food safety must be a top priority at every stage of food chain, including production, harvest, processing, storage, distribution, preparation, and consumption. qPCR method is used to detect the presence of particular DNA segments in samples, which helps in determining whether food contamination by biological agents occurred unexpectedly or on purpose. Moreover, qPCR is used to solve drawbacks of conventional food studies in terms of sensitivity, analyte diversity, multiplexing possibilities, cost, turnaround time, and point-of-care applications. Furthermore, qPCR may detect a number of targets, including used plant or animal species, even in extremely low amounts.
Restraint: Inconsistent false positive and negative results
Researchers typically view qPCR as a potential method that may deliver precise and quantitative data reflecting biology of experimental parameters under examination owing to availability of more sophisticated and precise qPCR techniques. Development of Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines and associated methodology articles help scientific community to improve experimental rigor and uniformity to generate more reliable and consistent data. A typical qPCR method also has a number of technical limitations, such as Reverse Transcriptase Real Time Polymerase Chain Reaction (RT-qPCR) experiment efficiency and yield, which can be adversely impacted by damaged or contaminated RNA, poor primer design, and failure to detect target molecules owing to low nucleotide count. Presence of contaminants in the sample can result in inaccurate quantification Cycle (Cq) intervals, which may come from host tissue or cells, qPCR or reverse transcriptase reaction enzymes, or both. Inconsistent data might also be caused by technical problems, such as incorrect dilution calculations or pipetting mistakes.,and failing to detect target molecules, owing to low nucleotide count.
Product Type Outlook:
Based on product type, the global qPCR market has been segmented into reagents and consumables, instruments, and software and services. The reagents and consumables segment revenue is expected to account for largest revenue share over the forecast period. qPCR reagents are required to identify nucleic acids that are important for diagnosis of diseases. In addition, to achieve specificity and sensitivity in qPCR, choosing right chemicals and reaction format is important. For real time PCR assay template, various reagents and assays used include complementary Deoxyribonucleic Acid (cDNA), upstream and downstream primers, Taq DNA Polymerase with reaction buffer, Deoxynucleoside Triphosphate (dNTP) mixture, molecular grade, Nuclease-Free Water, and real-time PCR Assay. Consumables include pipette, tips, PCR tubes, and racks, which are necessary items required to carry out a PCR reaction.
The instruments segment revenue is expected to grow at a moderate rate over the forecast period. Demand for technologically advanced products is rising as consumers’ preferences for updated and improved products grow. Significant technologically advanced products, such as Mic qPCR system with Bluetooth connectivity and numerous devices that may be linked to computer simultaneously to run different sample sets, are being driven by consumers’ growing taste for updated and improved products.
The software and services segment revenue is expected to grow at a steady rate over the forecasted period. Real-time PCR software and services (qPCR) aid in directing customers toward reliable data analysis, which are made to make gathering and analyzing real-time PCR data easier. Launch of software in aiding analysis of the data is further driving revenue growth of this segment. For instance, on 7 October 2020, the CFX Opus 96 and CFX Opus 384 Real-Time PCR Systems from Bio-Rad Laboratories, Inc., a pioneer in life science research and clinical diagnostic technologies, have been launched globally along with BR.io, a platform for cloud-based instrument communication, data administration, and analysis. Users can access cloud to check on the state of their instruments from any location due to interface with BR.io, which offers smooth data transfer.
Application Outlook:
Based on application, the global real time Polymerase Chain Reaction (qPCR) market has been segmented into blood and oncology testing, pathogen testing, Research & Development (R&D), forensic testing, and others. The blood and oncology segment accounted for largest revenue share in 2021. This is mainly attributed to increasing cancer cases worldwide and other chronic diseases, such as malaria and HIV, which requires blood samples for diagnosing. According to World Health Organization (WHO), African regions continue to bear a disproportionately large percentage of burden of malaria worldwide. 95% of all malaria cases and 96% of all malaria deaths in 2020 occurred in this region, while about 80% of all malaria deaths were in children under the age of 5.
The pathogen testing segment accounted for a moderate revenue share in 2021. It is now practically possible to build qPCR assays for every microbe of interest, as well as groups and subgroups of microorganisms, owing to growing amount of sequencing data accessible. With its increased specificity, dual-labeled fluorescence probe, such as TaqMan probe, has become a method of choice for identifying pathogens in environmental samples. This test has the benefit that probe, which detects internal amplicon sequences, verifies target amplicon.
The Research and Development (R&D) segment accounted for a moderate revenue share in 2021. This is owing to quantitative determination of gene copy number (gene dosage) in transformed cell lines or presence of mutant genes is frequently done in research labs using qPCR assays. For utilization of microarray technologies during drug development process to reveal potentially strong and reliable biomarkers, analytical validation of qRT-PCR assays capable of quantifying transcriptional biomarker levels precisely in therapeutically accessible matrices is necessary. Early drug target development focuses on exploring complex biological systems, to find disease mediators and confirm their therapeutic potential. Understanding the mechanisms underlying complex diseases and accelerating discovery of new drug targets can be accomplished by promoting translational research through transcriptome, proteome, and ultimately interactome analysis using a thorough workflow of fundamental tools, including qPCR, western blotting, and multiplex assaying.
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End-Use Outlook:
Based on end-use, the global qPCR market has been segmented into hospitals, diagnostic centers, Contract Research Organizations (CROs), forensic laboratories, pharma and biotech companies, and others. The hospital segment accounted for largest revenue share in 2021. This is mainly attributed to the increasing number of hospital admissions and regular testing of patient samples for chronic diseases such as hepatitis, and others. To prevent intra-hospital transmission of diseases that could be fatal to vulnerable patients and threaten accessibility and quality of healthcare, hospitals are under a lot of pressure to swiftly and properly identify infected patients and staff.
The diagnostic centers segment accounted for a moderate revenue share in 2021. Increasing availability of qPCR reagents for clinical diagnostic applications is a key factor driving revenue growth of this segment. On 23 June 2020, a state-of-the-art COVID Diagnostic Training Center has been established at Jakkur campus of Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), an independent research organization under the Department of Science & Technology, Government of India, to aid in e development of national capacity for COVID 19 pandemic response.
The pharma and biotech companies segment accounted for a moderate revenue share in 2021. A number of pharma and biotech companies are conducting tests for microbial contamination on drugs and other protein products using qPCR technique, which is driving revenue growth of this segment.
Regional Outlook:
Based on regional analysis, the North America market accounted for largest revenue share in 2021. Significant technological advancements in Real Time Polymerase Chain Reaction (qPCR) and presence of market companies are key factors driving market revenue growth in this region. The U.S. market accounted for largest revenue share. In addition, expansion of regulatory support and increase in introduction of novel products are other factors driving market revenue growth in this region. For instance, on 7 October 2021, Meridian Bioscience, Inc., which is a provider of diagnostic testing solutions and life science raw materials, announced to launch of its new Air-Dryable Direct RNA/DNA qPCR Blood Mix. It provides molecular diagnostic assays that directly amplify RNA from unprocessed whole blood, serum, or plasma and are stable at room temperature.
The Europe market is expected to register a moderate revenue growth rate over the forecast period. Increase in incidence of genetic and infectious diseases is a key factor driving market revenue growth of this region. According to World Health Organization (WHO), in 2020, there were 104,765 new cases of Human Immunodeficiency Virus (HIV) found in Europe. The UK market accounted for largest regional share. Compared to Germany and France, the UK spends more on healthcare. One of the key factors driving market growth is government’s emphasis on cutting-edge diagnostic methods for chronic diseases including cancer, malaria, and others. This is owing to Real-time PCR-based tools for COVID-19 screening and diagnosis that have improved the segment’s growth at an exponential rate owing to strong technological adoption. For instance, on 24 March 2020, Bruker Corporation announced an agreement for distribution of genesig real-time PCR coronavirus assay in the U.S., the UK, Spain, France, and Germany, with the subsidiary of Novacyt SA.
The Asia Pacific market accounted for a steady revenue share in 2021. Increase in investments in scientific research and rising cases of cancers are major factors driving market revenue growth. To lower the incidence of cancer in this region, government is contemplating and implementing a number of programs. For instance, National Cancer Control Program (NCCP) is a government-sponsored healthcare program created to reduce number of cancer patients and improve their quality of life. Implementing evidence-based preventative techniques is a part of this program, which will help patients financially by offering free examinations and treatment across India.
Competitive Landscape:
The competitive landscape of the global Real Time Polymerase Chain Reaction (qPCR) market is moderately consolidated with a few major companies operating on global and regional levels. Major companies are engaged in product development and strategic alliances to expand their respective product portfolios and gain a robust footprint in the global market. Some major companies in the market report include Abbott, Bio-Rad Laboratories Inc., Thermo FIsher Scientific, F. Hoffman-La Roche Ltd, BD, Agilent Technologies, Integrated DNA Technologies Inc., Standard BioTools, Takara Bio Inc., and Lumex Instruments.
Some recent developments are as follows:
- On 29 July 2022, Transgen Biotech Co., a manufacturer of molecular and cellular biology products based in Beijing, China announced to launch DV106 Monkeypox Virus (MPXV) Nucleic Acid qPCR Detection Kit. This kit is used to detect MPXV in clinical samples including blood, skin lesions, exudates, saliva, urine, nasal swabs, oropharyngeal swabs, saliva, and other clinical samples from probable cases of Monkeypox Virus (MPXV) infection.
- On 10 May 2022, Cipla Inc. in collaboration with Genes2Me Pvt. Ltd. announced to launch “RT-Direct” multiplex COVID-19 RT PCR Test kit in India. The Indian Council of Medical Research (ICMR)-approved Center validated this kit. It is based on the “gold standard RT-PCR method” and covers three target genes that are unique to SARS-COV-2 virus together with an Integrated Circuit (IC), making it significantly more sophisticated than methods that just cover one or two target genes. As a result, the RTPCR test’s sensitivity is significantly increased.
Segments Covered in the report
This report offers historical data and forecasts revenue growth at a global, regional, and country-level, and provides an analysis of the market trends in each of the sub-segments from 2019 to 2030. For the purpose of this report, Reports and Data has segmented the global Real Time Polymerase Chain Reaction (qPCR) market based on product type, application, end-use, and region:
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Real Time Polymerase Chain Reaction (qPCR) Market Report Scope
Segments covered By Product Type Outlook, Application Outlook, End-Use Outlook, Regional Outlook
By Product Type Outlook
- Reagents and Consumables
- Instruments
- Software and Services
By Application Outlook
- Blood and Oncology Testing
- Pathogen Testing
- Research and Development
- Forensic Testing
- Others
By End-Use Outlook
- Hospitals
- Research Laboratories and Academic Institutes
- Diagnostic Centers
- Contract Research Organizations (CROs)
- Forensic Laboratories
- Pharma and Biotech Companies
- Others
Regional scope
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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