The global peptide synthesis market size was USD 315 Million in 2020 and is expected to register a CAGR of 6.4% during the forecast period.
The global peptide synthesis market size was USD 315 Million in 2020 and is expected to register a CAGR of 6.4% during the forecast period. Major factors driving market revenue growth are increasing use of peptides in pharmaceutical drugs, rise in research activities and availability of funding for R&D, and the development of advanced peptide synthesizers.
Peptides are selective and efficacious signaling molecules that bind to specific cell surface receptors, such as G protein-coupled receptors (GPCRs) or ion channels, where these trigger intracellular effects. Given their excellent pharmacological profile and intrinsic properties, peptides represent an advantageous starting point for the design of novel therapeutics. Their specificity has been known to translate into excellent safety, tolerability, and efficacy profiles in humans.
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Market Dynamics
Driver: Increasing Use of Peptide Therapeutics
Compared to protein-based biopharmaceuticals, peptide therapeutics have a lower processing complexity and, as a result, lower production costs, which are closer to those of small molecules. The peptide synthesis market has exhibited a significant increase in sales as peptides strike a balance between small molecules and biopharmaceuticals. A variety of peptide technologies have emerged, in addition to traditional peptide designs, that represent growth opportunities and future directions in the peptide synthesis market. Multifunctional and cell penetrating peptides, peptide drug conjugates, and inventions based on alternate routes of administration are a few among them.
Range of applications for peptides has expanded over the last decade, from medicine and biotechnology to therapeutic peptide science. Peptide application is also undergoing a revival for commercial purposes, which is propelling the peptide synthesis market forward. For example, AbbVie’s peptide-based drug Lupron, which is used to treat prostate cancer and other conditions, had global sales of more than USD 752 million in 2020. In addition, Sanofi’s Lantus surpassed USD 7 billion in terms of revenue in 2017. There are currently more than 80 FDA-approved peptide medicines in the market, and this number is expected to rise dramatically, with approximately 140 peptide drugs in clinical trials and more than 500 therapeutic peptides in preclinical production.
Restraint: Hazardous Nature of Reagents and Solvents
Peptide synthesis is largely based on legacy technologies that employ vast quantities of highly volatile reagents and solvents with little attention paid to green chemistry and engineering. Lower efficiency, expensive biocatalysts, and lack of validation protocols are some disadvantages of this technology, which have made it difficult to produce peptides using enzymatic methods.
Key Takeaways:
Product Type Outlook:
On the basis of product type, the market is segmented into reagents, equipment, peptide synthesizers, chromatography equipment, and lyophilizer. In 2020, reagents segment accounted for the largest revenue share among other products in the peptide synthesis market. Growing application of peptides in therapeutics, drug design, and gene synthesis, increasing number of ongoing research projects involving peptide synthesis, and availability of various peptide synthesis reagents in the market are contributing to this segment’s growth.
Technology Outlook:
On the basis of technology, the peptide synthesis market has been segmented into solid-phase peptide synthesis, liquid-phase peptide synthesis, and hybrid and recombinant technology. Solid-phase peptide synthesis segment is expected to register a robust revenue CAGR during the forecast period. Solid-phase synthesis has many benefits, including ease of operation, simple purification, short development cycles, high-level automation, and the ability to synthesize long peptides from small amounts of amino acids.
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End-use Outlook:
On the basis of end-use, the peptide synthesis market is segmented into pharmaceutical and biotechnology companies, contract development and manufacturing organizations, and academic and research institutes. In 2020, pharmaceutical and biotechnology companies segment accounted for the largest revenue share, owing to increasing number of R&D projects in genomics, molecular biology, and related fields. Increasing application of peptides in drug discovery, therapeutics, and R&D investments would also drive this segment’s growth.
Regional Outlook:
North America accounted for the largest revenue share in the global market in 2020. This can be attributed to presence of major market players, increased availability of peptide synthesis technologies, as well as growing focus on producing peptide-based drugs on a commercial scale. Between 2015 and 2019, the U.S. Food Drug Administration (FDA) authorized a total of 208 new drugs, 15 of which were peptides or peptide-containing molecules, which account for 7% of the total number of drugs. Increased investment by regulatory bodies in pharmaceutical and biotechnological companies, as well as research institutes would also contribute to market growth in the region.
The peptide synthesis market in Asia Pacific is expected to develop at a fast pace, owing to increased investments by pharmaceutical and biotechnology companies, as well as rising number of R&D activities in the region. In addition, increased investments by market players, growing healthcare expenditure by governments, partnerships between multinational companies and local players for strengthening distribution networks, and higher prevalence of chronic diseases in low- and middle-income countries, would help Asia Pacific peptide synthesis market to grow at the fastest rate during the forecast period. For instance, the Indian pharmaceutical sector is expected to register a CAGR of 15% during the forecast period. India is the second-largest contributor to the global biotech and pharmaceutical workforce. The pharmaceutical sector size was valued at USD 33 billion in 2017. Size of the Indian healthcare sector, which is one of the fastest growing sectors, is expected to surpass USD 372 billion by 2022. By 2025, India’s biotech market size is estimated to reach USD 100 billion.
Competitive Landscape:
Competitive landscape of the global peptide synthesis market is moderately fragmented with a number of key players operating on global and regional levels. Key players are engaged in product development and strategic alliances to expand their respective product portfolio and gain a robust footprint in the global market. Some major companies present in the peptide synthesis market report are Genscript Biotech, Merck KGaA, Aapptec , Bachem Holdings , Anaspec, Biotage , CEM Corporation , Gyros Protein Technologies, Advanced Chemtech, and New England Peptide (NEP).
Segments covered in the report:
This report offers historical data points and forecasts and revenue growth at a global, regional, and country level, and provides analysis, industry trends, and consumption pattern details for each region, major country, and segment from 2018 to 2030. The global peptide synthesis market report includes industry trends, drivers, restraints, opportunities, threats, market strategies, segment revenue, and market share contribution by each regional and country market. In addition, the report offers industry analysis and competitive landscape, company financials, and impact analysis. The report includes a detailed view of the global peptide synthesis market, along with changing dynamics and trends, scenarios, detailed market and regional segmentation, regional landscape, analysis and evaluation, major investments, product offerings, product launches, and details of historical, current, and projected revenues.
For the purpose of this report, Reports and Data has segmented global peptide synthesis market on the basis of product type, technology, end-use, and region:
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Product Type Outlook (Revenue, USD Million; 2018 – 2030)
- Reagents
- Equipment
- Peptide Synthesizers
- Chromatography Equipment
- Lyophilizer
Technology Outlook (Revenue, USD Million; 2018 – 2030)
- Solid-phase Peptide Synthesis
- Liquid-phase Peptide Synthesis
- Hybrid & Recombinant Technology
End-use Outlook (Revenue, USD Million; 2018 – 2030)
- Pharmaceutical and Biotechnology Companies
- Contract Development and Manufacturing Organizations
- Academic and Research Institutes
Regional Outlook (Revenue, USD Million; 2018 – 2030)
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- France
- U.K.
- BENELUX
- Switzerland
- Rest of Europe
- Asia Pacific
- China
- Japan
- South Korea
- India
- Rest of Asia Pacific
- Latin America
- Brazil
- Rest of Latin America
- Middle East & Africa
- South Africa
- UAE
- Saudi Arabia
- Turkey
- Rest of MEA
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