Degenerative disc disease is one of today’s most common and costly medical conditions. Marked by the gradual erosion of cartilage between the vertebrae, this destructive disease of the spine routinely provokes low back pain, the leading cause of disability in people under age 45 in the United States. This condition is also confounding: the factors that account for the vulnerability of the disc to degeneration and the limited capacity of the disc for repair remain largely unknown. >>> Discuss This Story