The global immunoprecipitation market size was USD 621.96 million in 2020 and is expected to register a CAGR of 5.2% during the forecast period.
The global immunoprecipitation market size was USD 621.96 million in 2020 and is expected to register a CAGR of 5.2% during the forecast period. Steady market revenue growth is majorly supported by increasing number of research programs and initiatives in the life sciences industry, increasing R&D collaborations between academic institutes and leading pharmaceutical companies, technological advancements in immunoprecipitation techniques, and growing need for identifying antigens related to autoimmune diseases and developing relevant drugs.
Scientific breakthroughs in the fields of genetics and biological therapies, rising investments in biopharmaceutical R&D activities, increasing research initiatives in the areas of genomics, immunotherapy, drug development, personalized medicine are the others are fueling global market growth currently. In addition, rising significance of immunoprecipitation testing in treating cancer, cardiovascular diseases, and various central nervous disorders is further creating growth prospects for major players in this market.
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Immunoprecipitation (IP) refers to the process of precipitating a protein antigen using an antibody that binds to that specific protein. The technique is widely used for the isolation of a particular protein antigen from a sample comprising many different proteins. For this procedure, it is important for the antibody to be combined with a solid substrate. Immunoprecipitation involves immobilizing a specific antibody to a solid support such as agarose resin or magnetic particles for affinity purification of antigens. In simpler terms, this process is used to isolate a protein (the target antigen) determine its structure, identity, expression, and modification state. Several variations of this process also help examine the primary antigen protein’s interactions with other proteins and nucleic acids. However, the common goal is to study in detail the interactors or cellular components associated with the primary antigen. Immunoprecipitation is a widely used method for separation of proteins and various other biomolecules from tissue or cell lysates, which are subsequently examined through assay techniques such as western blotting. Individual protein immunoprecipitation, Co-immunoprecipitation (Co-IP), Chromatin immunoprecipitation (ChIP), and RNA Immunoprecipitation (RIP) are among the principal types of immunoprecipitation. In co-immunoprecipitation, the target antigen that has been precipitated by the antibody helps co-precipitate its binding partner. On the other hand, ChIP assays are performed for the identification of the genomic regions to which DNA-binding proteins such as histones and transcription factors are associated. Similar to ChIP, RNA immunoprecipitation identifies RNA-binding proteins using cDNA and RT-PCR sequencing techniques.
Global Immunoprecipitation Market: Dynamics
Drivers: COVID-19 pandemic and subsequent rise in adoption of chromatin immunoprecipitation is boosting market growth
Chromatin immunoprecipitation (ChIP) is an immunoprecipitation technique used to assess particular regions of the target DNA-binding protein’s genome. This technique finds significant applications in epigenetics research & development. The COVID-19 pandemic has resulted in significant increase in adoption of immunoprecipitation technique, as it plays a vital role in studying protein-DNA interactions and target binding sequences for the novel coronavirus. Increasing research activities for drug development, major focus on COVID-19 vaccine development, and advancements in applications of ChIP in genomic studies, and technological advancements in the ChIP procedure are pivotal factors fueling global immunoprecipitation market growth.
Restraints: Disadvantages associated with co-immunoprecipitation expected to hamper market growth
Contamination of antibodies is a common challenge associated with co-immunoprecipitation. However, several downstream applications such as western blot create additional bands in the gel. As a result of contamination, the light-chain and heavy-chain antibodies co-eluted with the protein complex often interfere with the protein identification process. Hence, such factors are expected to lower demand for the co-immunoprecipitation technique and thus restrict global market growth to some extent.
Global Immunoprecipitation Market: Product Type Outlook
Based on product type, the global immunoprecipitation market is segmented into kits, reagents, and accessories. The reagents segment dominated other segments in 2020, accounting for a significantly robust revenue share, and is expected to maintain its leading position throughout the forecast period. The reagents segment is further sub-segmented into antibodies (primary antibodies and secondary antibodies), beads (magnetic beads and agarose beads), and buffers. Extensive use of antibodies, buffers, and beads for various immunoprecipitation methods and growing usage of IP assays for isolation and purification of antigens are some key factors boosting revenue growth of this segment. Rising demand for agarose and magnetic beads across research laboratories for protein purification is another major factor expected to propel revenue growth of this segment going ahead.
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Global Immunoprecipitation Market: End-use Outlook
The global immunoprecipitation market has been segmented on the basis of end-use into pharmaceutical and biopharmaceutical companies, academic & research institutes, contract research organizations (CROs), and others. The academic & research institutes segment is projected to account for largest revenue share in the global market over the forecast period. Steady revenue growth of this segment is attributed to increase in research & development activities in the fields of molecular biology and genomics, rising government investments in academic R&D programs, and increasing research collaborations among academic organizations worldwide.
Global Immunoprecipitation Market: Regional Analysis
The global immunoprecipitation market is geographically segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. North America accounted for largest share in the global market in 2020 due to rising investments by governments and pharmaceutical and biotechnology companies in R&D activities, growing focus on personalized medicine, and increasing research collaborations between pharmaceutical companies and top academic institutions. Rapidly spreading COVID-19 virus across countries in the region and extensive use of advanced immunoprecipitation techniques in genome analysis and DNA-protein interactions are the other significant factors bolstering North America immunoprecipitation market revenue growth. The Asia Pacific market is projected to register highest revenue CAGR over the forecast period. Revenue growth of the market in this region is primarily attributed to increasing government investments in pharmaceutical and biotechnological R&D activities, growing adoption of personalized medicine, and presence of state-of-the-art healthcare infrastructure in Asia Pacific.
Companies Profiled in the Report:
Major companies operating in the global immunoprecipitation market include Thermo Fisher Scientific, Merck KGaA, Abbkine Scientific Co. Ltd., Abcam, Bio-Rad Laboratories, BioLegend, Cell Signaling Technology, GenScript Biotech Corporation, Rockland Immunochemicals, Takara Bio, and Geno Technology.
Some Key Developments:
- In February 2021, the National Institute of Allergy and Infectious Diseases (NIAID) began a Phase 1 clinical study aimed at determining the safety, efficacy, and immunogenicity of an Epstein-Barr virus gp350-Ferritin nanoparticle vaccine. These study successfully assessed the secondary immunogenicity endpoints of the vaccine using luciferase immunoprecipitation assay.
- In a 2020 study published in Bio-Protocol, the identification of DNA binding proteins using quantitative PCR (Chip-qPCR) and chromatin immunoprecipitation was discussed. According to the study, the immunoprecipitation techniques also detected histone modification on locus-specific areas of genome.
Global Immunoprecipitation Market Segmentation:
For the purpose of this report, the global immunoprecipitation market has been segmented based on type, product type, end-use, and region:
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Immunoprecipitation Market Report Scope
Segments covered By Type Outlook, Product Type, End-user, Regional Outlook
By Type Outlook
- Individual protein immunoprecipitation
- Chromatin Immunoprecipitation (ChIP)
- Co-immunoprecipitation (Co-IP)
- RNA Immunoprecipitation (RIP)
- Others
By Product Type
- Kits
- Accessories
- Reagents
- Antibodies
- Primary Antibodies
- Secondary Antibodies
- Beads
- Agarose Beads
- Magnetic Beads
- Buffers
By End-user
- Pharmaceutical and Biopharmaceutical Companies
- Academic & Research Institutes
- Contract Research Organizations (CROs)
- Others
Regional scope
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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