The global gene synthesis market size is estimated to garner around USD 17.99 billion by 2032 and is expanding at a healthy CAGR of 23.97% from 2023 to 2032.
The global gene synthesis market size is estimated to garner around USD 17.99 billion by 2032 and is expanding at a healthy CAGR of 23.97% from 2023 to 2032.
The gene synthesis market size was valued at USD 2.1 billion in 2022, grew to USD 2.60 billion in 2023. North America led the global market with the major market share of 39% in 2022.
Key Insights:
- In 2022, the solid-phase synthesis segment accounted for 37% of total revenue.
- In 2022, the antibody DNA synthesis segment has a 61% revenue share.
- In 2022, the development of gene and cell therapies accounted for 36% of total revenue.
- The segment generating revenue share of 56% in 2022 for academic and government research institutes.
Gene synthesis is a synthetic biology technique conducted in a laboratory involving engineering artificial genes. This method facilitates the transformation from a text-based genetic sequence to creating a physical genetic sequence with simplicity and high precision. It also involves the chemical process of constructing genes by forming nucleotides. Unlike natural gene synthesis that relies on DNA in living organisms, artificial gene synthesis doesn’t necessitate existing DNA; instead, it is chemically produced in labs by experienced professionals.
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The United States leads the market in North America, surpassing Canada and Mexico. The significant factors contributing to this dominance include the rising prevalence of genetic and chronic disorders, especially cancer, an ageing population, a growing demand for personalized medicine, and supportive government initiatives. The presence of key market players in the region and the substantial ongoing scientific research activities further contribute to the United States’ prominent position. For instance, In the fiscal year 2021, the National Cancer Institute of the United States received a dedicated budget of USD 6.56 billion for cancer research, emphasizing the country’s commitment to advancing medical knowledge.
Regional Stance:
Based on geography, North America is the largest region for the market for gene synthesis. The market is expected to grow due to increased research and development, new innovations made possible by genes, increased gene therapy, and an increase in chronic illnesses. With rising demands from the healthcare industry and a rise in gene therapies, the Asia Pacific area is expected to be the second-largest market for gene synthesis. The markets for gene synthesis are also expanding in other continents, including Europe, Latin America, the Middle East, and Africa.
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Gene Synthesis Market Scope
| Report Coverage | Details |
| Market Size in 2023 | USD 2.50 Billion |
| Market Size by 2032 | USD 17.29 Billion |
| Growth Rate from 2023 to 2032 | CAGR of 23.97% |
| Base Year | 2022 |
| Forecast Period | 2023 to 2032 |
| Segments Covered | Method, Service, Application, End Users, and Geography |
Growth Factors:
- Advanced technologies in gene synthesis, utilizing biological synthetic processes, have gained widespread acceptance in the market. The DNA-developed technology, focused on producing proteins and enhancing function, is a crucial driver for the gene synthesis market. The increased emphasis on research and technology for novel gene synthesis and using genes for innovative developments, especially in long-term therapies like targeted therapy and immunotherapy, contributes to market growth. The rising prevalence of chronic disorders, particularly oncological disorders, fuels the demand for new and innovative therapies. This trend is expected to propel the gene synthesis market forward during the forecast period.
- Global factors, including the ageing population and the increased prevalence of chronic diseases, are exerting continuous pressure on healthcare systems worldwide, contributing to the growth of the gene synthesis market. The prospect of personalized medicine offers the potential for enhanced patient care, increased safety, and reduced overall healthcare costs. For instance, data from the International Diabetes Federation (IDF) in December 2021 revealed that approximately 537 million adults (20-79 years) globally were living with diabetes. The IDF projected this number to escalate to 783 million by 2045, underscoring the urgency and significance of advancements in healthcare solutions, such as gene synthesis.
- Gene synthesis emerges as a critical driver of innovation, experiencing heightened demand in the medical sector. Professionals widely utilise gene synthesis, contributing to its significant role in the life sciences market. This sector fuels market growth through continuous advancements, particularly in diagnostic products for disorder diagnosis. Key market players actively engage in research and development, introducing biologically synthesised genes with increased investments in new technologies, variations, and enhanced gene efficiency. This progress is particularly impactful in addressing chronic disorders and supporting the substantial growth of the pharmaceutical industry.
- The integration of chemotherapy, immunotherapy, and targeted therapy is poised for substantial growth in the upcoming years, presenting lucrative opportunities for established and emerging healthcare companies. The increased focus on molecular-level research is expected to drive the demand for gene synthesis, particularly as clinical research intensifies. Looking ahead, advancements in synthetic biology may enable the creation of microorganisms designed to locate cancer cells. These engineered microbes could release targeted toxic proteins, eliminating cancer cells with minimal side effects and enhanced precision.
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Market Potential:
PCR-mediated recombination is a standard method for constructing chimeric infectious molecular clones of plasma-derived HIV-1 RNA. In gene synthesis, chemical synthesis typically forms oligonucleotides up to 120-150 nucleotides in length. Gene assembly techniques connect these shorter oligonucleotides to achieve the required gene length. Over three decades, various methods have emerged for assembling short synthetic oligonucleotides into longer gene sequences. PCR-mediated assembly is a prominent approach for achieving the desired DNA sequence. Moreover, market players are enhancing the polymerase chain reaction technique for increased nucleic acid synthesis capacity. For instance, in April 2020, Biolytic Lab launched Dr Oligo 768XLc DNA RNA Synthesizer, an advanced high-throughput nucleic acid synthesiser, signalling significant growth potential for the segment.
Advanced gene therapy, utilising innovative technologies and novel therapies, drives the gene synthesis market. This involves the insertion of genes into patients’ cells, enhancing the gene’s efficiency for long-term disease treatment with significant benefits. Growing demands from the medical sector, coupled with improved technologies for treating disorders, contribute to the expanding market for gene synthesis.
The increasing demand for advanced recombinant DNA technologies drives significant market players to pursue mergers, collaborations, and acquisitions to broaden their market reach. For instance, Eurofins Scientific, a prominent testing laboratory company, acquired a U.S.-based biotechnology firm in August 2019, enhancing its gene synthesis capabilities. This trend, coupled with intensified research and development for novel therapeutics and diagnostics, is poised to fuel market growth.
Related Reports:
- DNA Synthesis Market: The global DNA synthesis market size was estimated at USD 3.50 billion in 2022 and it is expected to surpass around USD 20.87 billion by 2032, growing at a CAGR of 19.6% during the forecast period 2023 to 2032.
- Cell and Gene Therapy Market: The global cell and gene therapy market size was reached at USD 15.46 billion in 2022 and is expected to hit around USD 82.24 billion by 2032, poised to grow at a CAGR of 18.3% from 2023 to 2032.
- Gene Editing Market: The global gene editing market size was exhibited at USD 6.94 billion in 2022 and is projected to hit around USD 29.93 billion by 2032, growing at a CAGR of 15.73% during the forecast period from 2023 to 2032.
Industry Spotlight:
- On November 14, 2023, Twist Bioscience, a synthetic biology and genomics company, unveiled Express Genes, a new gene synthesis service with an expedited turnaround of five to seven business days. This service in the company’s Wilsonville, Ore., manufacturing facility enables swift gene production.
- On July 3, 2023, UK-based synthetic biology company Camena Bioscience revealed the closure of a $10 million Series A financing round led by UK venture capital firm Mercia. The fresh funding will empower Camena to expand operations and advance the development of gSynth, its enzyme-based DNA synthesis platform.
- In July 2022, OraSure Technologies introduced the OmniGene Gut DNA and RNA product (OMR-205) for gut microbiome researchers.
- In April 2022, DNA Script initiated an early access program, providing organisations with the latest enzymatic DNA synthesis technology advancements through the SYNTAX system.
Market Key Players:
- OriGene Technologies,Inc
- Integrated DNA Technologies, Inc
- Thermo Fisher Scientific, Inc
- ProMab Biotechnologies, Inc
- Eurofins Scientific
- Biomatik
- ProteoGenix
- Bosyer Biological Technology
- GenScript
- Brooks Automation, Inc (GENEWIZ)
- Twist Bioscience
- Codex DNA
Company Synopsis:
Integrated DNA Technologies, Inc
A leading supplier of custom nucleic acids, Integrated DNA Technologies (IDT) specialises in producing DNA and RNA oligonucleotides for research applications in academic, biotechnology, clinical diagnostics, and pharmaceutical development. Integrated DNA Technologies (IDT) announced its entrance into the CRISPR therapeutics space by opening a new therapeutic manufacturing facility in October 2023. This strategic move positions the company as a singular partner for researchers, enabling an accelerated path to the clinic.
GenScript
GenScript Biotech, a China-based provider of life science research services and products, is well-regarded for its gene synthesis capabilities, making it a preferred service for academics, biotech companies, and pharmaceutical firms worldwide. On November 10 2023, GenScript ProBio, a global multimodality CDMO, and specialised CAR-T therapy firm Curocell signed a strategic partnership MOU. This collaboration marks a significant milestone in their ongoing partnership and is focused on producing vital viral vectors for advancing the next generation of CAR-T therapy.
Market Segmentation
By Method
- Solid-phase synthesis
- Chip-based synthesis
- PCR- based Enzyme synthesis
By Service
- Antibody DNA synthesis
- Viral DNA synthesis
- Others
By Application
- Gene & cell therapy development
- Vaccine development
- Diseases diagnosis
- Others
By End Users
- Biotechnology & pharmaceutical companies
- Academic & government research institutes
- Contract research organizations
By Geography
- North America
- Europe
- Asia-Pacific
- Latin America
- Middle East & Africa (MEA)
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