Bone Grafts and Substitutes Market Size to Surpass USD 3.96 Billion by 2030

According to Report, the global bone grafts and substitutes market was estimated at USD 2.80 billion in 2020, and is predicted to surpass around USD 3.96 billion by 2030 with a CAGR of 6.1% from 2022 to 2030.

Growth Factors

The rising incidence of bone and joint disorders, increasing demand for dental bone grafts, growing requirement for dental bone grafts, and technological advancements are some key factors driving the market. The synthetic material type segment is anticipated to witness significant growth over the forecast period. This growth is due to the lesser risk of disease transmission, better acceptance among patients as compared to allografts, and products’ better biocompatibility.

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One of the key factors fueling the growth of the market is the rising incidence of bone and joint disorders. According to the CDC report, the global incidence rate of hip fracture is expected to rise by 240% in women and 310% in men. Osteoporosis is estimated to affect around 200 million women worldwide. Moreover, the rising demand for dental bone grafts is expected to drive the market for bone grafts and substitutes over the forecast period.

The demand for orthopedic devices, which include bone grafts and substitutes, observed a radical decrease because of the rescheduling of elective surgeries during COVID-19. During the pandemic, various players in the market were negatively impacted and hence they adopted various strategies to deal with the pandemic. 

Growing cases of spinal deformities are driving this market. According to a CDC report, approximately 60% of the aged population and 32% of the adult population are suffering from spinal deformities, in the U.S., as of 2017. Around 488,000 spinal procedures were performed in the U.S. Moreover, the introduction of biocompatible synthetic grafts is expected to fuel market growth. 

Report Coverage

By Application Analysis

The spinal fusion segment held the largest revenue share of over 60.0% in 2021. Based on application, the market is classified into long bone, spinal fusion, foot and ankle, joint reconstruction, craniomaxillofacial, and dental.

The growth can be attributed to the rising adoption of bone graft materials for spondylosyndesis. Moreover, the rising geriatric population prone to orthopedic ailments is pushing the need for corrective surgical treatment, thereby anticipated to boost the market growth in the near future.

Increasing usage of grafts for dental procedures is estimated to provide lucrative opportunities for the segment to grow through the forecast period. The grafts are usually used as a scaffold and filler in order to facilitate bone formation and promote healing. 

The joint reconstruction segment is expected to witness steady growth over the forecast period owing to the increasing number of knee replacement and hip replacement procedures. According to the center for orthopedic and neurological care and research, the number of total knee replacement surgeries is estimated to increase by 673% to 3.5 million procedures annually, by 2030.

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By Material Type Analysis

The allograft segment led the market and accounted for over 55.0% share of the global revenue in 2021. The allograft segment is further divided into the demineralized bone matrix and others

The adoption of allografts is increasing due to their properties, such as immediate structural support and osteoconductivity. Additionally, they do not require another surgery bone, which triggers fast wound healing and decreases the surgery time.

The synthetic segment is anticipated to witness significant growth over the forecast period. This growth is due to the products’ better biocompatibility, lesser risk of disease transmission, and better acceptance among patients as compared to allografts. 

The synthetic segment is further classified into composites, ceramics, polymers, and BMP. The ceramics segment dominated the market in 2021 and is further sectioned into HAP, ß-TCP, α-TCP, bi-phasic calcium phosphates (BCP), and others. Ceramic material gets easily reabsorbed in a patient’s body, which maintains the position of their bone and has a reduced risk of infection or disease transmission.

By Regional Analysis

North America dominated the market with over 40.0% share of the global revenue in 2021. Growing awareness related to the commercially accessible innovative products, accessibility of a well-developed healthcare structure, and higher healthcare expenditure of 16.9% in 2018 is the major aspects contributing to the regional market growth.

Asia Pacific is estimated to witness lucrative growth during the forecast period. This growth can be attributed to rising medical tourism and favorable government initiatives. On the other hand, stringent regulatory guidelines restrict the adoption in a few nations.

Key Players

• AlloSource
• DePuySynthes, Inc.
• Baxter
• Nuvasive, Inc.
• Smith & Nephew
• Medtronic
• Orthofix Holdings, Inc.
• TBF Tissue Engineering
• OST Devloppement
• Zimmer Biomet
• Wright Medical Group N.V.
• GeistlichPharma AG
• Stryker Corporation
• Biobank

Market Segmentation

• By Material Type 
  • Allograft
    • Demineralized Bone Matrix
    • Others
  • Synthetic
    • Ceramics
      • HAP
      • β-TCP
      • α-TCP
      • Bi-phasic Calcium Phosphates (BCP)
      • Others
    • Composites
    • Polymers
    • Bone Morphogenic Proteins (BMP)
• By Application 
  • Craniomaxillofacial
  • Dental
  • Foot & Ankle
  • Joint Reconstruction
  • Long Bone
  • Spinal Fusion
• Regional
  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • U.K.
    • France
    • Italy
    • Spain
  • Asia Pacific
    • China
    • India
    • Japan
    • South Korea
  • Latin America
    • Brazil
    • Mexico
  • MEA
    • South Africa

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