Peptide Synthesis Market Size To Reach USD 516.75 Million in 2028, Says Reports and Data

Development of technologically advanced peptide synthesizers and availability of various peptide synthesis reagents are driving market revenue growth

The global peptide synthesis market size is expected to reach USD 516.75 Million in 2028 registering a CAGR of 6.4% over the forecast period, according to a latest report by Reports and Data. Major factors driving market revenue growth are availability of funding for R&D, increasing use of peptides in pharmaceutical drugs, development of technologically advanced peptide synthesizers, and rising research activities worldwide.

Peptides are selective and efficacious signaling molecules that bind to specific cell surface receptors, such as G Protein-coupled Receptors (GPCRs) or ion channels, where these trigger intracellular effects. Given the excellent pharmacological profile and intrinsic properties, peptides represent an advantageous starting point for the design of novel therapeutics. Its specificity has been known to translate into excellent safety, tolerability, and efficacy profiles in humans.

When compared to protein-based biopharmaceuticals, peptide therapeutics have a lower processing complexity and, as a result, lower production costs, which are closer to those of small molecules. The peptide synthesis market has seen a significant increase in sales as peptides strike a balance between small molecules and biopharmaceuticals.

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A variety of peptide technologies have emerged, in addition to traditional peptide design, that represent growth opportunities and future directions in the peptide synthesis market. Multifunctional and cell penetrating peptides, peptide drug conjugates, and inventions based on alternate routes of administration are a few among these.

Range of application for peptides has expanded over the last decade, from medicine and biotechnology to therapeutic peptide science. Peptide application is also undergoing a revival for commercial purposes, which is propelling the peptide synthesis market forward. For example, AbbVie's peptide-based drug Lupron, which is used to treat prostate cancer and other conditions, had global sales of more than USD 752 million in 2020. In addition, Sanofi's Lantus surpassed USD 7 billion in revenue in 2017. There are currently more than 80 FDA-approved peptide medicines in the market, and this number is expected to rise dramatically, with approximately 140 peptide drugs in clinical trials and more than 500 therapeutic peptides in preclinical production.

However, the current peptide synthesis is largely based on legacy technologies that employ vast quantities of highly volatile reagents and solvents with little attention paid to green chemistry and engineering. Lower efficiency, expensive biocatalysts, and lack of validation protocols are some disadvantages of this technology, which have made it difficult to produce peptides using enzymatic methods.

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Some Key Highlights from the Report:

  • In 2020, reagents segment accounted for the largest revenue share in the peptide synthesis market, owing to availability of various peptide synthesis reagents and ongoing research projects involving peptide synthesis.
  • Solid-phase peptide synthesis segment is expected to register a robust revenue CAGR during the forecast period. This growth is attributable to its ability to synthesize long peptides from small amounts of amino acids.
  • In 2020, pharmaceutical and biotechnology companies segment accounted for the largest revenue share, owing to increasing number of R&D projects in genomics, molecular biology, and related fields.
  • North America accounted for the largest revenue share in the global market in 2020, owing to increased investment in pharmaceutical and biotechnological companies, as well as research institutes by regulatory bodies.
  • The peptide synthesis market in Asia Pacific is expected to develop at the fastest rate, owing to increased investments by pharmaceutical and biotechnology companies, as well as rising number of R&D activities in the region.
  • Some major companies profiled in the peptide synthesis market report are Genscript Biotech, Merck KGaA, Aapptec , Bachem Holdings , Anaspec, Biotage , CEM Corporation , Gyros Protein Technologies, Advanced Chemtech, and New England Peptide (NEP).

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Segments covered in the report:

For the purpose of this report, Reports and Data has segmented global peptide synthesis market on the basis of product, technology, end-use, and region:

Product Outlook (Revenue, USD Million; 2018 – 2028)

  • Reagents
  • Equipment
  • Peptide Synthesizers
  • Chromatography equipment
  • Lyophilizer

Technology Outlook (Revenue, USD Million; 2018 – 2028)

  • Solid-phase Peptide Synthesis
  • Liquid-phase Peptide Synthesis
  • Hybrid & Recombinant Technology

End-use Outlook (Revenue, USD Million; 2018 – 2028)

  • Pharmaceutical and Biotechnology Companies 
  • Contract Development and Manufacturing Organizations
  • Academic and Research Institutes

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Regional Outlook (Revenue, USD Million; 2018 – 2028)

  • North America
    • US
    • Canada
    • Mexico
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Benelux
    • Rest of Europe
  • Asia Pacific
    • China
    • India
    • Japan
    • South Korea
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Rest of Latin America
  • Middle East and Africa
    • Saudi Arabia
    • UAE
    • South Africa
    • Turkey
    • Rest of Middle East & Africa

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