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California-based biotech Nuvig Therapeutics scooped up $161 million from the investment arms of Sanofi, Bayer, Novo Holdings, BMS and others for its Fc fragment immunomodulator aimed at improving autoimmune dysregulation.

Juvena Therapeutics today announced the U.S. Food and Drug Administration (FDA) granted Orphan Drug designation to the company’s flagship candidate, JUV-161. JUV-161 is an investigational therapeutic for the treatment of Myotonic Dystrophy Type 1 (DM1), a rare, multi-systemic, autosomal dominant inherited disease and the most common form of adult muscular dystrophy.

IDEAYA Biosciences, Inc. announced that it has entered into a clinical trial collaboration and supply agreement with Merck to evaluate IDE161, the company’s investigational, potential first-in-class, small molecule poly glycohydrolase, or PARG, inhibitor, in combination with KEYTRUDA® Merck’s anti-PD-1 therapy, in patients with microsatellite instability-, or MSI-, high and microsatellite stable, or MSS, endometrial cancer, in a Phase 1 clinical trial.