ChemDiv Inc. (Chemical Diversity) is a global chemistry-driven contract research organization focused on identifying and delivering discovery opportunities and services for life science partners, and merging industrial and academic efforts to bring new approaches to the treatment of life-threatening diseases.
Over 17 years ChemDiv provides Discovery outSourceTM solutions including medicinal and synthetic chemistry, pre-clinical development, screening libraries, compound management and global logistics.
ChemDiv’s synthetic chemistry expertise includes:
• Heterocyclic Chemistry
• Modern organic synthesis technics
• Organometalic chemistry;
• Microwave assisted synthesis, both liquid and solid phase;
• Highthrouput analysis and purification (LCMS, HPLC, multi-nuclear NMR, mass-directed HPLC, SPE, UV FPLC)
• Solid support chemistry
• Optically active materials
• Special conditions
CUSTOM SYNTHESIS
• Proprietary client’s target or scaffold based library design and parallel synthesis (20 – 2000 analogs/scaffold)
• Exclusive or semi-exclusive modification of ChemDiv’s proprietary library systems
• Broad or specific chemical and biological annotation
• Proprietary collection of>4000 highly functionalized building blocks
• Development and transfer of protocols and key intermediates
• Material(s) delivery on a 1 mg - 10 kg scale, > 90-99% purity
• High-throughput 1H NMR, MS/HPLC and purification
ANNOTATED LIBRARY SYSTEMS
ChemDiv has designed and validated the largest portfolio of chemical library systems based on > 5500 heterocylic scaffolds, diverse reactions and building blocks. Libraries could be customized according to partner specifications within broad chemistry space with minimum redevelopment effort.
Library system design strategies:
• Proven synthetic feasibility
• Privileged structure search, literature annotation
• Knowledge mining for IP score optimization (SciFinder, Beilstein, Integrity)
• Rational design, bioisosteric morphing
• Natural-like peptidomimetic and lead-like motifs and structures
• Optimization of diversity and phys-chem parameters
• ADMETox parameters optimization
Annotation with in vitro and in vivo experimental biology data
ChemDiv is the partner of choice for screening libraries due to its experience in building a library of close to 1 million drug-like compounds that meet the criteria of the pharmaceutical industry's hit-to-lead discovery process.
FEATURES OF THE SCREENING LIBRARIES INCLUDE:
More than 10,000 chemical templates representing over 1 million compounds
200,000 new compounds based on 1,500 new templates
developed annually
Pre-filtration using Rule-of-Five analysis and MedChem filters
Comprehensive QC of all compounds
Compound replenishing and back-up guarantee
FOCUSED DIVERSITY™ APPROACH
The Focused Diversity™ approach and computational algorithms have been developed to assist in the analysis of chemical space, and characterization of target/ligand interactions:
Fragment and property based diversity, completeness and lead likeness
Strategic surveillance and novelty assessment
Feasibility, parallel synthesis and validation
Unique intermediate and protocol development
QSAR and non-linear modelling
High throughput QC
Data mining and IT platform integration
PRECLINICAL DEVELOPMENT
ChemDiv's preclinical development services in combination with its extensive medicinal and synthetic chemistry expertise facilitates drug discovery projects of our partners through:
The Focused Diversity™ approach to design of screening libraries
Development of assay systems based on in-house or third-party targets
Development and optimization of primary and secondary screens
Assay adaptation and optimization for high-throughput screening formats (96, 384)
Medicinal chemistry and optimization of hits and leads
In vitro and in vivo ADMET, and animal models
A multi-disciplinary team of 500 research scientists, technical support and customer service personnel that operate out of facilities in San Diego, USA, and Moscow, Russia.
With its world class capability and infrastructure, ChemDiv is the partner of choice for chemistry-driven drug discovery.
Toll free: 1-877- CHEMDIV
Web site: www.chemdiv.com