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Amendment extends TEM relationship beyond Panama into additional Latin American markets, adds VIVI Med(TM) to the distribution framework, and supports broader regional availability following product registrations Highlights TempraMed and TEM Consulting International S.A. execute amendment expanding the distribution relationship beyond Panama to additional Latin American markets. • The amended framework adds VIVI Med™ to the covered product portfolio, alongside VIVI Cap™ and VIVI Epi™. • TempraMed received an additional commercial order from TEM, expected to be fulfilled by the end of September 2026. • Initial extended-territory framework contemplates minimum units across the added countries, with additional annual commitments tied to exclusivity. • Once required registrations are completed, TempraMed products are expected to be available through distribution relationships covering seven Latin American countries representing a substantial majority of the region’s population. • TempraMed expects to raise up toC$1,000,000 through non-brokered private placement of Units

— First-in-Human Study: Completion of dosing was achieved in PMG1016-1031 Phase 1a Study in Healthy Volunteers —

Company outlines broader scientific-development priorities focused on microbiome research, formulation evaluation, and long-term growth.

While Acadia Pharmaceuticals’ candidate has missed the main goal of a Phase 2 trial, the company is still moving forward with the anti-psychosis candidate in Alzheimer’s disease as well as Lewy body dementia.

Analysts were keen to see a new modality compete with Roche’s approved drug Lucentis in the late-stage trial but new safety issues could complicate the future for Merck’s candidate.