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Tristan Manalac

Tristan Manalac

Contributing Writer | News

Tristan is an independent science writer based in Metro Manila, with more than eight years of experience writing about medicine, biotech and science. Being formally trained in molecular biology, he once dreamed of collecting degrees and starting his own lab. But these days, he finds his greatest joy in a bottle of beer and a beautiful sentence. He can be reached at tristan.manalac@biospace.com, tristan@tristanmanalac.com or on LinkedIn.

Pictured: J&J's building in Switzerland
Drug Development
ASCO24: J&J Reports Four Patient Deaths in Early-Stage Prostate Cancer Trial
Johnson & Johnson’s radiopharma candidate JNJ-6420 returned mixed results in an early-stage study, demonstrating strong biochemical and radiographic response but also resulting in four patient deaths.
May 24, 2024
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2 min read
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Tristan Manalac
Pictured: Facade of Takeda's office in Massachusetts
Business
Takeda Joins Hot Molecular Glue Market With $1.2B Deal
Riding the growing wave of interest in molecular glue degraders, Takeda has partnered with Chinese biotech Degron Therapeutics to develop novel therapies for oncology, neuroscience and inflammation.
May 23, 2024
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2 min read
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Tristan Manalac
Pictured: Sign above the entrance to a U.S. courthouse
Policy
Appeals Court Sides With Drugmakers in 340B Case, Allows Limits on Discounts Under Program
An appellate court ruled on Tuesday that pharmaceutical companies can lawfully impose restrictions on covered drugs under the 340B Drug Pricing Program.
May 23, 2024
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2 min read
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Tristan Manalac
Facade of Novo Nordisk's office in Fremont, California
Policy
FDA Flags Hypoglycemia Risk for Novo’s Once-Weekly Insulin Ahead of Adcomm
In advance of Friday’s Endocrinologic and Metabolic Drugs Advisory Committee meeting, the FDA has raised concerns about hypoglycemia linked to Novo Nordisk’s insulin icodec, according to a briefing document.
May 23, 2024
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2 min read
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Tristan Manalac
Pictured: Pfizer's signage outside its office in Canada/iStock, JHVEPhoto
Business
Pfizer Targets Another $1.5B in Cost Cuts By End of 2027
Amid its ongoing efforts to trim $4 billion in spending in 2024, Pfizer in an SEC filing on Wednesday said it is looking to save an additional $1.5 billion over the next several years.
May 23, 2024
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2 min read
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Tristan Manalac
Pictured: Biogen's headquarters in Cambridge, Massachusetts
Deals
Biogen Beefs Up Immuno Pipeline with Potential $1.8B HI-Bio Acquisition
Days after backing out of two Ionis-partnered neuro programs, Biogen has inked a potential $1.8 billion buy of Human Immunology Biosciences and boosting its late-stage immunology pipeline.
May 22, 2024
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Tristan Manalac
Pictured: 3D illustration of antibody-drug conjugates with their toxic payloads
Pheon Raises $120M in Series B to Advance ADCs for Hard-to-Treat Cancers
London-based Pheon Therapeutics will use the funds to push its three lead antibody-drug conjugate candidates through clinical proof-of-target studies.
May 22, 2024
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Tristan Manalac
Pictured: Pfizer's signage at its world headquarters in New York
Policy
Wyden Targets Pfizer in Ongoing Pharma Tax Investigation in Letter to CEO
As part of an ongoing Senate investigation into pharma companies’ tax rates, Sen. Ron Wyden (D-Ore.) has asked Pfizer CEO Albert Bourla to explain irregularities in its reported revenues, losses and taxes paid.
May 22, 2024
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Tristan Manalac
Pictured: J&J's office in Madrid, Spain
Drug Development
J&J Positions Tremfya as Stelara Successor with Strong Head-to-Head Data
Johnson & Johnson on Tuesday released Phase II/III results showing its monoclonal antibody Tremfya is better than its blockbuster Stelara in terms of endoscopic outcomes in Crohn’s disease.
May 22, 2024
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Tristan Manalac
AstraZeneca's sign on its office in California
Business
AstraZeneca Sets $80B Revenue Target, Goal of 20 New Drugs by 2030
AstraZeneca on Tuesday laid out an ambitious plan to boost growth in its existing oncology, biopharma and rare disease portfolios, as well as launch 20 new medicines before the end of the decade.
May 21, 2024
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Tristan Manalac
Pictured: Doctor holding up a lung x-ray
Drug Development
Sanofi, Regeneron Post Strong Phase III COPD Data for Dupixent as FDA Decision Looms
Late-stage results from the NOTUS trial showed Sanofi and Regeneron’s Dupixent lowered moderate to severe chronic obstructive pulmonary disease exacerbations by 34% and led to significantly better lung function.
May 21, 2024
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2 min read
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Tristan Manalac
Pictured: Man carrying a box of his office items after being laid off
Policy
BIO Axes 30 Staff in Realignment as Congress Advances BIOSECURE Act
Following its recent about-face on the BIOSECURE Act, designed to combat China’s influence in the biopharma industry, lobbying group Biotechnology Innovation Organization in a realignment is laying off 30 employees.
May 21, 2024
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Tristan Manalac
FDA signage at its office in Maryland
FDA
FDA Greenlights Two Interchangeable Biosimilars to Regeneron’s Eylea
The regulator on Monday approved two interchangeable biosimilars to Regeneron’s Eylea, providing additional competition for the pharma’s blockbuster as key patent protections are set to expire.
May 21, 2024
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Tristan Manalac
Pictured: A graphic showing figures on opposing coin stacks
Business
9 Top Biopharma CEO-to-Employee Pay Gaps
Despite weathering a difficult year, biopharma continues to see massive pay gaps between CEOs and their median employees, with top executives often earning hundreds of times more.
May 21, 2024
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9 min read
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Tristan Manalac
Pictured: AstraZeneca's building in Shanghai, China
Drug Delivery
AstraZeneca to Build $1.5B ADC Manufacturing Plant in Singapore
To support its growing antibody-drug conjugate portfolio, AstraZeneca on Monday said it is investing $1.5 billion in a Singapore production site that will include all steps of the ADC manufacturing process.
May 20, 2024
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2 min read
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Tristan Manalac
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