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Company Profile


Cara Therapeutics, Inc. 

One Parrott Drive

Shelton  Connecticut  06484  U.S.A.
Phone: 203-567-1500 Fax: 203-567-1510


Cara Therapeutics is a clinical-stage biotechnology company focused on developing and commercializing new chemical entities designed to alleviate pain and pruritus by selectively targeting kappa opioid receptors. Cara is developing a novel and proprietary class of product candidates that target the body's peripheral nervous system and have demonstrated activity in patients with moderate-to-severe pain without inducing many of the undesirable side effects typically associated with currently available pain therapeutics.

CR845 is a peripherally acting kappa opioid receptor agonist currently in development for the treatment of acute and chronic pain and pruritus. In multiple randomized, double-blind, placebo-controlled Phase 2 trials in patients undergoing laparoscopic hysterectomy or bunionectomy procedures, I.V. CR845 treatment resulted in statistically significant reductions in both pain intensity and opioid-related side effects. In more than 440 subjects dosed to date, I.V. CR845 was observed to be well tolerated, without incurring the dysphoric and psychotomimetic side effects that have been reported with centrally acting (CNS-active) kappa opioid receptor agonists. Cara recently initiated its Phase 3 program with I.V. CR845 in postoperative pain. Cara also has an ongoing Phase 2 trial of an oral tablet formulation of CR845, for the treatment of osteoarthritis (OA).

Key Statistics

Ownership: Public

Web Site: Cara Therapeutics
Symbol: CARA

Company News
Cara Therapeutics (CARA) To Webcast Presentation At The Piper Jaffray 27th Annual Healthcare Conference 11/25/2015 7:53:01 AM
Cara Therapeutics (CARA) To Webcast Presentation At The Stifel 2015 Healthcare Conference 11/11/2015 10:21:28 AM
Cara Therapeutics (CARA) Reports Third Quarter 2015 Financial Results 11/10/2015 7:54:25 AM
Cara Therapeutics (CARA) To Announce Third Quarter 2015 Financial Results On November 9, 2015 11/3/2015 8:57:26 AM
Cara Therapeutics (CARA) To Present At 2nd Human Abuse Liability & Abuse-Deterrent Formulations Conference 10/26/2015 7:25:24 AM
Cara Therapeutics (CARA) To Sponsor Symposium And Present Poster At ANESTHESIOLOGY 2015 10/19/2015 8:19:23 AM
Cara Therapeutics, Inc. (CARA) Achieves Milestone Payments From Japan And South Korea Partners For Development Of CR845 In Uremic Pruritus 10/13/2015 7:43:43 AM
Cara Therapeutics, Inc. (CARA) To Present At The American Academy Of Physical Medicine And Rehabilitation Annual Assembly 9/29/2015 7:06:52 AM
Cara Therapeutics, Inc. (CARA) To Present Data At The 8th World Congress On Itch 9/22/2015 8:39:47 AM
Cara Therapeutics, Inc. (CARA) Initiates Phase III Program For I.V. CR845 In Acute Postoperative Pain 9/9/2015 7:22:47 AM