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Company Profile


Aerpio Therapeutics 

9987 Carver Road
Suite 420
Cincinnati  Ohio  45242  U.S.A.
Phone: 513-985-1920 Fax: 513-985-0999


Aerpio Therapeutics is a new, clinical-stage biotechnology company focused on the development of novel small molecules and monoclonal antibodies for the treatment of vascular disease and enhancement of wound healing. Aerpio was created in a spin-out transaction from Akebia Therapeutics to enable more rapid development of its exciting compounds.

Aerpio's two lead programs include a Tie-2 activator for diabetic macular edema (DME) and vascular leak, and a Hypoxia-inducible Factor 1-a (HIF1-a) stabilizer for wound healing and the treatment of inflammatory bowel disease. The lead compound for the Tie-2 program, AKB-9778, is currently completing its initial Phase 1 clinical trial, and the HIF1-a stabilization program is progressing toward the clinic with support, in part, from the United States Department of Defense and National Institutes of Health.

The Aerpio team is composed of highly experienced individuals from all facets of pharmaceutical development. During the last 4 years, this team has successfully sharpened their skills at Akebia Therapeutics in the fast paced world of venture backed biopharmaceuticals.

Key Statistics

Ownership: Private

Web Site: Aerpio
Employees: n/a


Company News
Akebia (AKBA) Spinoff Aerpio Scores $40 Million 3/16/2017 6:33:20 AM
Aerpio Raises $40 Million 3/16/2017 6:09:08 AM
Aerpio Initiates Phase Ia Study Of AKB-4924, A First In Class Once-Daily, Orally Administered HIF-1 Stabilizer, In Development To Treat Inflammatory Bowel Disease (IBD) 9/26/2016 11:20:53 AM
Aerpio Reports Peer-Reviewed Publication Of Positive Clinical Results From The Phase IIa Study Of Lead Candidate, AKB-9778, In Diabetic Macular Edema (DME): The TIME-2 Trial 6/13/2016 10:28:06 AM
Aerpio Announces Presentation Of Positive Results Of AKB-9778 In Patients With Diabetic Retinopathy From TIME-2 Phase IIa Study 2/10/2016 10:34:50 AM
Aerpio Reports Positive Clinical Results From The Phase IIa Study Of Lead Candidate, AKB-9778, In Diabetic Macular Edema (DME): The TIME-2 Trial 11/17/2015 10:00:56 AM
Aerpio Appoints Steve Pakola, M.D. As Chief Medical Officer 10/6/2015 10:42:17 AM
Aerpio Announces Positive Results Of A Phase IIa Study Of AKB-9778 In Diabetic Macular Edema: The TIME-2 Trial 7/15/2015 9:59:52 AM
Aerpio To Present At The 14th Annual Needham Healthcare Conference 4/9/2015 10:02:31 AM
Aerpio Announces Publication Of Positive Results Of Phase 1b/2a Clinical Trial Of Novel Tie2 Activator, AKB-9778, For The Treatment Of Patients With Diabetic Macular Edema (DME) – TIME-1 Study 3/4/2015 9:00:04 AM