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Scientist I, II; Sr. Scientist I, Protein Chemistry

Employer
Omeros Corporation
Location
Seattle, WA
Start date
Jun 19, 2024

View more

Discipline
Science/R&D, Biotechnology, Chemistry
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
BioForest

Job Details

Scientist I/II/Sr. Scientist I, Protein Chemistry

 

The Protein Chemistry Group at Omeros Corporation, located in Seattle, WA, provides expertise in protein design, production, and analytics to support the discovery and early development of bio-therapeutics across disease states. 

 

Reporting to the Director, Protein Chemistry, you will be responsible for providing technical and project level support towards developing and implementing core productions techniques and collaboratively guiding efforts toward selection of candidate therapeutic modalities.  Furthermore, you will work 100% on-site to design and conduct experiments aimed toward the production/generation of high-quality protein reagents that support program aims and data integrity. This is an on-site position located in Seattle, WA.

        
Good things are happening at Omeros!

Come join our Omeros Discovery Team!

 
Who is Omeros? 

Omeros is an innovative biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, immunologic diseases (e.g., complement-mediated diseases) and cancers. Omeros’ lead MASP-2 inhibitor narsoplimab targets the lectin pathway of complement and is the subject of a biologics license application pending before FDA for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Narsoplimab is also in multiple late-stage clinical development programs focused on other complement-mediated disorders, including IgA nephropathy, atypical hemolytic uremic syndrome and COVID-19. OMS906, Omeros’ inhibitor of MASP-3, the key activator of the alternative pathway of complement, is in a Phase 1 clinical trial. For more information about Omeros and its programs, visit www.omeros.com.


What are your job responsibilities?

  • Protein design, production and analytics supporting the discovery and early development of bio-therapeutics across disease states
  • Responsible for providing technical and project level support towards developing and implementing core productions techniques.
  • Design and conduct experiments aimed toward the production/generation of high-quality protein reagents that support program aims and data integrity.
  • Collaboratively guide efforts toward selection of candidate therapeutic modalities
  • May mentor Research Associates/junior Scientists dependent upon the level

  • Education, Experience, Skills, & Knowledge Required:

    •         With a protein production focus, minimum education requirements include either a Bachelor’s degree in a related field with a minimum of 12+ years relevant industry experience; a Master’s degree in a related field with a minimum of 8+ years relevant industry experience or a PhD in a related field with a minimum of 0-2 years of relevant experience in industry or academia (level is additionally determined by skills and knowledge)
    •         Significant repertoire of technical skills in recombinant protein expression (E. coli and HEK) and protein purification (AKTA, Chromatography), with demonstration of the theoretical basis and experimental design for recombinant protein production
    •      Experienced in delivering high-quality and characterized protein reagents for in-vitro and in-vivo experiments and demonstrating independent troubleshooting in vector-to-protein sample workflows
    •      Skilled in data analysis and conveyance of interpreted results in project and management team settings, along with ability to directly impact the protein engineering design cycle
    •      Techniques for protein quality attributes, including purity, size, aggregation state, and endotoxin measures.
    • Additional expertise that can benefit the position includes:
      •   Biophysical & protein analytical techniques (SPR or Octet, mass-spec (peptide, intact), UPLC (Reversed Phase, aCEX, aHIC), protein stability measures; or,
      •   Protein conjugation techniques and related analytical experience; or,
      •   Structure-based protein modeling tools (Schrodinger, MOE, Rosetta, etc); or,
      •   Development of stable cell lines aimed at therapeutic protein production

     

    Behavioral Competencies Required:  

    •     Builds collaborative relationships at the group and interdepartmental levels
    •     Provides interpretation of production and functional relationship results to help guide selection of therapeutic modalities
    •     A passion for professional self-development

     

    Physical Demands Required:  

    • Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 40 lbs.  
    • May encounter prolonged periods of sitting or standing  
    • This position requires working around hazardous materials

     

    Compensation and Benefits:

    Omeros is proud to offer a competitive total compensation package designed to support the lives of our employees and their families. The wage scale for this position is Scientist I (105,000-128,000); Scientist II (120,000-145,000); Sr Scientist (125,000-160,000) per year.  Salaries will be determined based on knowledge, skills, education, and experience relevant to the role.  Employees are offered medical, dental, vision and life insurance and a 401k plan with a company match.   Employees accrue three weeks of vacation and 80 hours of sick time on an annual basis and receive ten paid holidays throughout the calendar year.  This position is eligible for bonus and stock options. To learn more about Omeros, please visit www.omeros.com.

    Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

    It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to  hr@omeros.com  or contact Omeros, asking for Human Resources, at (206) 676-5000.

     

    Company

    At Omeros, we are proud of our innovative and cutting-edge science. Our world-class team has achieved scientific advances that no other group has been able to accomplish, delivering wholly new classes of therapeutics to benefit patients. We let science lead the way.

    From our foundation of groundbreaking science, we continue to build and advance a deep and diverse pipeline of small-molecule and protein therapeutics. We are not interested in developing “me-too” products; instead, we are focused on tackling challenging diseases and disorders with significant unmet medical needs. The result is an exciting pipeline of first-in-class drugs with new mechanisms of action that target previously untapped receptors and enzymes.

    The Omeros team is exceptionally talented, passionate, collaborative and diverse. We hire smart, creative and hard-working people who want to play a meaningful part in building a preeminent biopharmaceutical company. We come from all corners of the globe, bringing unique abilities and experiences together to provide hope to patients and their families.

    Company info
    Website
    Phone
    206.676.5000
    Location
    201 Elliott Avenue West
    Seattle
    Washington
    98119
    US

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